Marine extract compositions and methods of use

ABSTRACT

Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts. Production of collagen, elastin and hyaluronic acid are increased after application of the compositions.

BACKGROUND OF THE INVENTION

Skin is affected by many factors, including ultraviolet light, air &topical pollution, wind, heat, humidity, soaps, and other environmentalelements. Additionally, biological changes, including chronological age,health and life style can effect the quality of the skin.

Typical skin problems are fine lines, wrinkles, and sagging. Aging andsun damage to the skin causes alteration, destruction and diminishedbiosynthesis of the major components of the dermis (the second layer ofthe skin). When we consider aging skin we are generally thinking aboutthe visible effects: sagging, wrinkled skin with a coarse texture, largepores and increasing numbers of lentigines (small pigmented spots) andactinic keratoses (a growth of precancers on the skin). The principalcause of skin aging is two-fold; a slowdown in the production of extracellular matrix (ECM) component which is accompanied by a diminishedcapacity to handle the production workload efficiently. The causes ofvisible aging skin are related to diminished biosynthesis of the threemajor components of the ECM: collagen, elastin and hyaluronic acid.Where we observe sun damage and aging of the skin, we observe the lossof these building blocks of our skin. In addition, fibrocytes, the cellswhich make collagen, elastin and hyaluronic acid and microcirculation,which nourish the skin also decreases in number and function by about 3%per year after the age of 30.

Collagen gives strength and toughness to the skin. It acts asscaffolding for elastin and hyaluronic acid. Loss of collagen results inweak and easily tom skin.

Elastin gives the elastic rebound. Skin loses its bounce with the lossof elastin. This results in skin having a crêpey appearance with awrinkled surface and thin skin with a tendency to sag.

Hyaluronic acid gives the skin volume and provides a great deal ofprotective insulation. Loss of hyaluronic acid leads to thin,translucent skin, where blood vessels appear more prominent and themicrovasculature becomes visible. The skin appears pink and displays theepidermal aspects of sun damage, which include “liver” (age) spots,which in reality are sunspots (called lentigines). The skin also becomeseasily bruised and torn.

These are the supporting structures of the skin; collagen fibers providethe scaffolding that supports the epidermis, while elastin fibers givethe skin its resiliency and firmness. Hyaluronic acid is made up of longchain sugar molecules that form a gel that holds up to 6,000 times itsweight in water. Hyaluronic acid is essential to healthy skin because itincreases the water content of the epidermis and gives the skin itspleasing plumpness and pliability.

People start losing these essential components of skin at a young ageand sun damage contributes dramatically more loss. After age 30, theamounts of collagen, elastin and hyaluronic acid decreases about 1-2%per year, and aging and sun damage combined can cause a loss of theseessential components upwards of 3% per year.

In addition the ratio of healthy new cells to defective cells (that looklike unsightly age spots, etc.) shrinks. Replacement of new tissue takeslonger (cell turnover rate slows), so in addition to wrinkles andsagging the skin becomes dull, coarse, blotchy and hyper pigmented.

The reason behind this litany of negative effects is simple andfamiliar; as a person ages, hormone production slows down. Hormoneinsufficiency dictates a slowdown of a number of processes, includingthose affecting the appearance of the skin.

Aging and sun damage also dramatically reduce the number and activity ofoil glands (called sebaceous glands) in the dermis. These glands alsosecrete the body's natural sunscreen (called squalene). The epidermis(the outer layer of the skin) then becomes dry and cracked and lessprotective.

The deterioration of the dermis directly affects the epidermis.Epidermal cell division decreases, the replacement of old tissue withnew, healthy cells takes longer. The skin becomes thin and vulnerable.In this condition, the skin is more sensitive to outside contactants.Contactants are allergens that can cause dermatitis.

Injections of collagen or hyaluronic acid add no more than temporaryimprovement. They do not organize those materials in a functionalpattern. The materials are placed in globs that fill in thedeterioration of the skin's natural composition. The effect ofinjections doesn't last because the collagen, elastin and hyaluronicacid are torn down by the fibroclasts. There is no improvement in thenumber or function of fibrocytes and blood vessels.

There are many products available over the counter or from a physicianthat are directed toward improving the health and physical appearance ofthe skin. The products try to delay or minimize the production ofwrinkles or even try to eliminate wrinkles once they have formed.

Consumers prefer topically applied products due to their ease of use.The strongest topical treatment on the market is currently Retin-Acream. Others include alpha hydroxy acid and vitamin C creams. Thesehave been shown to minimally increase collagen production. They donothing to increase elastin and hyaluronic acid, or number and functionof fibrocytes or blood vessels. Although the skin may appear betterafter treatment, there is still the same number of cells after treatmentas there were before treatment. Once treatment is stopped, the skinreturns to the pre-treatment status in about 1 to 2 weeks. This may bedue to the cells overworking during the Retin-A treatment, which mayshorten the cells life span.

Scientists around the world are increasingly recognizing therejuvenating powers of the ocean. They realize that the same forces thatcreated life play a huge role in regenerating life. People areinterested in using natural or organic products for skin care in thebelief that these products are safer and more effective. Of interest tothese people are products from the ocean. Organisms from the ocean arebelieved to have beneficial compounds and salts.

A focus has been placed on marine algae and organisms that eat algaesince they will concentrate the compounds form the algae. The abalone(Haliotis spp.), in particular, has been investigated for its beneficialeffects. There have been reports that abalone has antiviral andantibacterial activity when injected into mice. Also, there is antidotalevidence that the guts from abalone contain a photoactive chemical thatcauses cats to have skin damage after exposure to light. Additionally,the severity of the skin damage varies during the year.

While there are many products that take advantage of the flora from thesea by adding macroalgae extracts there are very few that are usingmarine fauna. Adding biopeptides from gastropods is a cutting-edge idea.This idea, which is about to transform anti-aging skin care as we knowit, is complemented by the unique extraction technology that compromisesneither product efficacy nor customer safety.

The desire of the public for products from the ocean and suggestionsthat some marine organisms contain unknown chemicals led to theinvestigation of extracts from several marine organisms—algae,cyanobacteria and animals.

SUMMARY OF THE INVENTION

The investigation of extracts from marine organisms led to findings ofextracts that stimulate the production of cellular products and hormonesinvolved in regulating crucial skin regenerative processes.

Extracts from algae and seaweed contain peptides which speed healing bypromoting cell growth, nourishing the skin with vitamins and mineralsand enhancing barrier function. Adding the peptides places the stimulantand the raw materials in the same application. Instead of adding the rawmaterials alone, including the stimulants to organize these rawmaterials recreates the natural function of the skin.

Probably the most dramatic impact of aging and sun damage is the deathof fibrocytes, which create and maintain skin and its components and theproliferation of fibroclasts which dissolve degenerating components. Thenet result is that the skin decreases 2-3% of its collagen, elastin andhyaluronic acid, fibrocytes and blood vessels each year after the age of30. There is no substance, no cream that has ever been shown to increasefibrocyte and blood vessel formation in the skin. The extractincorporates the natural building blocks into functional skin bystimulating not only the reproduction of fibrocytes but also newcollagen, elastin and hyaluronic acid in patterns that maximize skinfunction.

The effect of creams and injectables containing collagen, elastin andhyaluronic acid is temporary at best and far less functional. Simplyproviding the raw materials does not incorporate them into the skin.Only the fibrocytes and fibroblasts will do this.

Among the components in the extracts are specific concentrations ofthree prostaglandin subtypes that improve the scaffolding of the dermisby stimulating the fibrocytes to produce more collagen, elastin andhyaluronic acid.

Fibrocytes do far more than produce collagen, elastin and hyaluronicacid. They organize these substances into a highly functional unitcalled the dermis, which is the “cow hide” or “body” of the skin.

Fibroclasts are cells that dissolve damaged and altered collagen,elastin and hyaluronic acid. This is an essential function. Unless thefibroclasts dissolve damaged skin and the fibrocytes replace what thefibroclasts have taken away with new, intact skin, age and sun damagewill impair skin function and rob the skin of its healthy look.

With age, however, and as sun damage occurs, fibroclastic activitydominates over fibrocytic activity. Without fibrocytes to replace whatthe fibroclasts take away, the skin loses functionality. We seedegeneration and are left with thinner, weaker, less functional skin.The decreased fibrocytic activity and increased fibroclastic activitydeteriorate the skin and also reduce its ability to regenerate itself.

An action of the extracts is that the stimulation of the fibrocytes toreproduce. Compared to the diminished ability of aged and sun damagedskin, the extracts provide an exponential increase in collagen, elastinand hyaluronic acid. The sheer level of production of these substancesis unmatched by any competing product. It can only be explained by thedirect stimulation of fibrocytes to divide into fibroblasts (juvenilefibrocytes). It is the only way to recreate the youth of the skin. Theextracts create young, plump, highly productive fibroblasts.

The extracts are more effective than any “rejuvenating” cream on themarket today because they stimulate the fibrocytes to do more thanproduce collagen, elastin and hyaluronic acid: it stimulates thefibrocytes to divide into fibroblasts. Thereby, the extracts rejuvenatethe skin in a much quicker, more functional and long lasting way.Without this action, the improvement would be slow, linear andtemporary. By stimulating the production of fibrocytes, the improvementbecomes more exponential and permanent. The difference in action isobvious to the eye.

Other products achieve only a minor stimulation of existing fibrocytes.They could never improve the overall skin quality the way these extractsare able to do it. The extracts have shown to be effective in even themost aged and sun damaged skin. The extracts actions go beyond thenormal capability of aging skin. They act as a “reset button” bothvisually and microscopically.

As the extracts stimulate the dermis to become healthier, the dermis inturn stimulates cell reproduction in the epidermis. This createshealthier skin altogether smoother, fuller, and less blotchy. Theextracts improve the entire skin which is different than other products.

While this improvement originates below the surface in the dermis, theextracts also improve the metabolism and reproduction of the epidermisdirectly.

Stimulation from a single topical application can last up to three tofour weeks and the effects seem to be permanent. After maximizing thestimulation by front-loading the product, maintenance applications willcontinue to provide improvement by raising the levels of the threemajor, structural components of the skin and increasing the number offibrocytes that produce these building blocks and blood vessels whichnourish them.

The extracts work with nature to give back to the skin what the agingprocess has taken away from it, components that are destroyed,diminished or altered in both the aging and the sun-damaged skin.

These same stimulating actions of not only increasing fibroblast andblood vessel numbers and function but also collagen, elastin andhyaluronic acid production have been shown to improve the speed andquality of healing wounds, especially in older people. Several patientshave used the extracts on dressings with tremendous success onrecalcitrant ulcers of bed sores and diabetics. These extracts are alsoexpected to dramatically improve the healing of third degree burns.Formal FDA studies are planned.

The active components in the extracts fight pre-cancers and thestructure of the dermis and epidermis that creates them. Researchindicates that the extracts are delivered through the Langerhans cells.Langerhans cells have “fingers” that reach into the epidermis to deliverthe active chemicals in the extracts and further stimulate the T cellmediated immune system.

The extracts decrease sunspots (lentigines) and vascular blemishes, notto mention the substantial improvement of the overall quality andthickness of the skin. The extracts improves the thickness of the skinin patients with Rosacea, which camouflages the underlying bloodvessels. A thicker dermis does not influence the flushing episodes; itchanges the appearance of the blood vessels. The skin is thicker andthereby covers the blood vessels.

Additionally, the extracts improve the overall health of the epidermisand dermis to improve the skin barrier in patients with dry, irritatedand sensitive skin. This results in less irritation and betterresistance to infection. It also allows for further hydration of a muchthicker dermis and epidermis.

The improved barrier function and faster cell turnover rate means theskin is better able to prevent further damage in sun damaged skin whilerepairing existing damage. By improving the skin's health, the extractsalso improve secretion by the sebaceous glands, which produce naturaloils including squalene, the body's natural sunscreen. This furtherprotects the increasingly healthy, treated skin.

Natural marine extracts stimulate the immune system to kill pre-cancers,and to produce more blood vessels and fibrocytes. Plus stimulating thefibrocytes themselves to produce more collagen, elastin and hyaluronicacid.

It will be clearly understood that while the invention is described indetail with reference to compounds detected in the viscera, thesecompounds, when present in or extracted from whole animals or partsthereof, are still within the scope of the invention. The disclosureincludes compositions comprising an active compound as described above,together with a pharmaceutically-suitable carrier or diluent.

Methods are disclosed for treating or alleviating damage to skin, causedby ultraviolet irradiation, ionizing radiation, microwave radiation,exposure to ozone, or the like, comprising the step of topicallyadministering an effective amount of a disclosed compound to a subjectin need of such treatment. It may be used in the treatment of solarkeratosis and skin damage occurring during radiotherapy.

The mammal may be a human, or may be a domestic or companion animal.While it is particularly contemplated that the compounds of theinvention are suitable for use in medical and cosmetic treatment ofhumans, it is also applicable to veterinary treatment, includingtreatment of companion animals such as dogs and cats, and domesticanimals such as horses, cattle and sheep, or zoo animals such as felids,canids, bovids, and ungulates.

The disclosed compounds and compositions may be administered by anysuitable route, and the person skilled in the art will readily be ableto determine the most suitable route and dose for the condition to betreated. Dosage will be at the discretion of the attendant physician orveterinarian, and will depend on the nature and state of the conditionto be treated, the age and general state of health of the subject to betreated, the route of administration, and any previous treatment whichmay have been administered.

The carrier or diluent, and other excipients, will depend on the routeof administration, and again the person skilled in the art will readilybe able to determine the most suitable formulation for each particularcase. It is contemplated that compounds of the invention may beadministered topically. Methods and pharmaceutical carriers forpreparation of pharmaceutical compositions are well known in the art.

For the purposes of this specification it will be clearly understoodthat the word “comprising means including but not limited to” and thatthe word “comprises” has a corresponding meaning.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWING

FIG. 1 shows the sex distribution of the patients in the study of theextract composition.

FIG. 2 shows the age distribution of the patients in the study of theextract composition.

FIG. 3 shows the percentage of patients in each age group who showedimprovement in wrinkles, rosacea, bruising and thin skin after the useof the extract composition.

FIG. 4 is a photograph showing the histology of a tissue sample from thehand of a patient after treatment with the extract composition.

FIG. 5 is a photograph showing the histology of a tissue sample from thehand of a patient before treatment with the extract composition.

FIG. 6 is a photograph of the hands of a patient showing the physicalappearance before treatment (right hand) and after treatment (left hand)with the extract composition.

DETAILED DESCRIPTION OF THE INVENTION

The extracts work to reverse the skin aging process and improve andunsightly damaged skin and pre-cancers. The extracts cause thestimulation of the following productive processes, increase collagenproduction, increase elastin production, increase hyaluronic acidproduction and improve cell turnover rate

The results from application of the extracts, as determined by in vivotrials, showed that the dermis becomes thicker giving smoother surfaceappearance, skin becomes firmer with less sagging, diminished number ofdisfiguring age spots while the old ones fade and new ones do notappear, skin has a more consistently even appearance as healthyepidermal layers replace damaged areas, skin texture improves as healthycells outnumber defective cells and sufficient supplies of HA ensurethat skin appears hydrated, less wrinkled and healthy

Abalone Extract

The extract stimulates the T-cell mediated immune system through theLangerhans cells. The stimulation can last up to three to four weeks.The results were quantified with the use of a Canfield VisiaComputerized Imaging System.

In addition, abalone extract stimulates fibrocysts (fibroblasts) toproduce collagen, elastin and hyaluronic acid in the dermis of the skin.Other rejuvenating creams on the market today either directly providecollagen, hyaluronic acid and elastin which the skin can not efficientlyutilize or they provide peptides which cannot stimulate the biosynthesisof collagen, hyaluronic acid and elastin as effectively as the extract.The extract does the best job of working with nature to give back whatthe aging process has taken away. These are the components of the skinwhich are destroyed, diminished or altered in both the aging and thesun-damaged skin. The collagen provides strength and toughness to theskin; its loss creates very feeble, easily torn skin. The elastinprovides elastic rebound and without it, the skin has tremendouswrinkling and “hangs”. The hyaluronic acid provides the “substance” orthickness of the skin. Without it, the skin becomes thin (at timestranslucent) and bruises very easily. Abalone extracts works better thanall of the “rejuvenating” creams on the market today.

The beneficial effects of abalone extracts were thoroughly tested andquantified by using a “wrinkle index” and precise skin thicknessmeasurements on the Canfield Imaging System.

These same stimulating actions of not only increasing fibroblast andblood vessel numbers and function but also collagen, elastin andhyaluronic acid production have been shown to improve the speed andquality of healing wounds, especially in older people. Several patientshave used the extracts on dressings with tremendous success onrecalcitrant ulcers of bed sores and diabetics. These extracts are alsoexpected to dramatically improve the healing of third degree burns.Formal FDA studies are planned.

Body Structure of Abalone

Abalone have a simple body structure with a large columnar muscleattached to the muscular foot, and a visceral mass, attached to the leftside of the columnar muscle, which wraps around the columnar muscle tothe right. The visceral mass includes the gills, stomach, heart andconical appendage. The conical appendage includes the digestive gland,which is surrounded by the gonad. The sexes are separate in abalone withindividuals either male (testes) or female (ovary).

Body Structure of Bivalves

The visceral mass is located between a pair of shells. The pair ofadductor muscles open and close the shells to allow respiratory andfeeding. The sexes can be separate with male and female individuals orthey can be hermaphroditic with both sexes present.

Body Structure of Sea Cucumber Sea Cucumbers are soft-bodied echinodermstypically vermiform in shape. It is radially symmetrical along itslongitudinal axis. Inside the body wall is the coelom which is dividedby three longitudinal mesenteries which surround and support theinternal organs.Body Structure of Crustacean

Crustaceans have a hard exoskeleton protecting the visceral mass. Thevisceral mass can be generally separated into 3 tissues—muscle, visceraand gonad.

Tissue Preparation—Abalone

a. The animal is removed from its shell.

b. The visceral mass is separated from the columnar muscle.

c. The conical appendage is cut-off from the visceral mass to obtain twotissue samples.

d. The conical appendage includes the digestive gland and gonad tissue

d. The gonad surrounding the digestive is removed and kept as a separatetissue sample.

e. The abalone is divided into 5 separate tissue samples—columnarmuscle/foot, viscera, digestive gland, testes and ovary.

Tissue Preparation—Bivalve

a. The animal is removed from its shell.

b. The visceral mass is separated from the adductor muscles.

c. The visceral mass can be further prepared by removing the gonad

e. The bivalve is divided into 3 separate tissue samples—adductormuscle, viscera, and gonad.

Tissue Preparation—Sea Cucumber

a. The body of the animal is sliced along the length of the body toexpose the viscera.

b. The gonad is separated visceral mass.

c. The 5 muscles are removed from the body wall.

e. The sea cucumber is divided into 4 separate tissue samples—body wall,muscle, viscera, and gonad.

Tissue Preparation—Crustacean

a. The outer exoskeleton is removed and the visceral mass is collected.

b. the gonad and muscles are removed from the visceral mass.

e. The crustacean is divided into 4 separate tissue samples—exoskeleton,muscle, viscera, and gonad.

Tissue Preparation—Algae/Cyanobacteria

a. New, actively growing fronds are removed from macroalgae.

b. The whole organism is collected and concentrated for microalgae andcyanobacteria

Extraction Process

The tissue sample is obtained from the organism and stored on ice untila sufficient quantity of tissue is obtained.

The tissue can either be frozen for processing at a future time ortransferred directly to the next step in the process. If the tissue isfrozen, it can be further processed by freeze drying/lyophilization toincrease shelf life.

The collected tissue is placed in a blender, homogenizer, grinder orsimilar machine to mechanically break up the cells in the tissue.

Optionally, the tissue can be directly extracted with an appropriatepolar and/or non-polar solvent (water, alcohol, hexane, chloroform,ether, or other suitable solvent) to obtain fractions containing activecompounds or the tissue can be passed to the next step with extractionwith a solvent.

If the tissue was not freeze dried after the collection step andprocessed as fresh tissue, the processed tissue is frozen/freeze driedor just dried.

The dried tissue is place into a mortar and pounded with a pestle tomake a powder. The collagen can be separated from the powder by screenfiltering. The collagen gets caught in the screen, and the powder fallsthrough. The collagen is discarded.

If the tissue sample has not already been extracted with solvents, thepowder is extracted with polar and/or non-polar solvents to obtainfractions with the active compounds.

The tissue sample can be centrifuged or filtered to remove cellulardebris. Also, the solvent fraction can be further processed by columnchromatography, HPLC or other similar separation technique.

The powder is reconstituted in an appropriate carrier solvent or thefractions obtained by extracting the powder are mixed with a deliveryvehicle.

The reconstituted powder is used in the disclosed compositions.

Observed Results of Extracts from Abalone, Bivalves, Sea Cucumbers,Crustaceans, Algae and Cyanobacteria

The extracts rejuvenated the skin with increased production offibrocytes and new blood vessels. Elastin, collagen and hyaluronic acidproduction was stimulated to allow the skin to regain elastic rebound,thickness and strength. Stretch marks, wrinkles, laugh lines, fold linesand muscle-wrinkles disappeared after the application of the extracts.

The extracts resolved problems with thin, fragile, easily torn skin dueto age and/or sun damage. Additionally, the extracts caused thedisappearance of skin ulcers in elderly and diabetics patients,pre-cancerous lesions on the skin, translucence of the skin in theelderly, and rosacea. The treatments with the extracts caused areduction or disappearance of hot flashes in the face, less bruising,improved healing of wounds.

The results were permanent (subject to the normal rate of aging) with adisappearance of pre-cancerous lesions, sunspots (lentigines) andvascular blemishes.

Definitions

Extract—the term “extract” as used in this disclosure refers to 1) apreparation containing the active ingredient of a substance inconcentrated form; 2) a solution of plant or animal tissue containing anactive principle; 3) a solid, viscid, or liquid substance containing theessence or active substance of a food, plant, or drug in concentratedform; 4) obtaining a substance by chemical or mechanical action, as bypressure, distillation, or evaporation; 5) obtaining a substance from amixture or material by a chemical or physical process, such asdistillation, the action of a solvent, or separation by a physicalcharacteristic of a chemical or compound (e.g., molecular weight; size;shape; affinity, relative affinity or lack of affinity to a solvent oraffinity, relative affinity or lack of affinity between a gel and asolvent; etc.). An extract is a complex mixture of chemicals andcompounds, whose composition (quantity and ratio of compounds) isdetermined by various factors, including the tissue extracted, speciesof organism, solvent or solvents used during the extraction and order ofsteps in the extraction process. Two extracts will be different if thefactors during the extraction process are different.

Fraction—A chemical component separated by fractionation. A quantitycollected from a sample or batch of a substance during fractionationwhere a mixture is separated into different parts. The separableconstituents of a substance, tissue or mixture.

Fractionation—a separation process in which a certain quantity of amixture (solid, liquid or suspension) is divided up in a number ofsmaller quantities (fractions) in which the composition varies accordingto the selection criteria (e.g., molecular weight; size; shape;affinity, relative affinity or lack of affinity to a solvent oraffinity, relative affinity or lack of affinity between a gel and asolvent; etc.). Fractions are collected based on differences in aspecific property of the individual components. Fractionation ofcomponents also takes place in column chromatography by a difference inaffinity between stationary phase and the mobile phase.

Tissue—the term “tissue” as used in this disclosure means the collectivegroup of cells, tissues or organs associated together in an organismidentified by a common name; e.g., frond, gonad, viscera, columnarmuscle, digestive gland, conical appendage, etc. The term “tissue” asused in this disclosure is not limited to the scientific classificationof the four basic types of tissue: muscle, nerve, epidermal, andconnective.

Abalone tissue extract—an extract obtained from any tissue from anabalone.

Alga tissue extract—an extract obtained from any tissue from an alga.

Bivalve tissue extract—an extract obtained from any tissue from abivalve.

Crustacean tissue extract—an extract obtained from any tissue from acrustacean.

Cyanobacteria extract—an extract obtained from a cyanobacteria.

Molluscan tissue extract—an extract obtained from any tissue from amollusc.

Sea cucumber tissue extract—an extract obtained from any tissue from asea cucumber.

Marine—the term “marine” as used in this disclosure refers to organisms(animals, plant and cyanobacteria) that live in water with at least somesalinity. The water could be called oceanic, sea, brackish or estuarine.Marine is to be given its widest meaning for water with salt.

Drying—any method that reduces the water content, including natural airdrying, supercritical drying, freeze drying, lyophilization, convectiveor direct drying, spray drying, drum drying, vacuum drying, microwave,refractance window drying, infrared zone drying and simple dehydration.

Other Ingredients

The disclosed compositions can comprise one or more of the followingcosmetic product as an ingredients acetyl hexapeptide-3 (argirilene),acrylates/C₁₀₋₃₀ alkyl acrylate cross-polymer, Actinidia deliciosa(kiwi) seed oil, algae extract, Andropogon zizanioides (vetiver)essential oil, Aniba rosaeodora (rosewood) essential oil, apricot kerneloil, Arctostaphylos uva ursi extract, Argania spinosa (argan) oil,argirilene, astaxanthin, beta glucan, Borago officinalis (borage) oil,Boswellia carterii (frankincense) essential oil, Caesalpinia spinosa(tara) gum], calcium carbonate, Camellia oleifera (camellia) oil,Camellia sinensis, Cannabis sativa (hemp) seed oil, caprylic/caprictriglyceride], Carica papaya (papaya) seed oil, cellulose gum, Centellaasiatica (gotu kola) extract, ceramide 1, ceramide 3, ceramide 6 II,ceramide complex, cetearyl glucoside, chitin, chitosan, cholecalciferol(vitamin D3), cholesterol, Citrullus lanatus (watermelon) extract,Citrus aurantium (neroli) hydrosol, Citrus paradisi (grapefruit)essential oil, Cocos nucifera (coconut) oil, coenzyme Q10, Crithmummaritimum (sea fennel) extract, decyl polyglucoside, dipeptidediaminobutyroyl benzylamide diacetate (snake peptides), elastin,Enteromorpha compressa extract, fatty acids, gamma-oryzanol,geranylgeranone gga, gluconolactone, glucosamine, glycan booster[tetradecyl amino-butyroylvalyl-aminobutyric urea trifluoro-acetate,glycerin, Glycine soja (soybean) oil, glycoproteins, Glycyrrhiza glabra(licorice root) extract, green tea extract, Gynostemma pentaphyllum(gynostemma) extract, Haematococcus pulvialis, Helianthus annuus(sunflower) seed oil, homeostatine, hyaluronic acid, hydrolyzed ricebran extract, hydroquinone, lactoceramides, Lavendula angustfolia(lavender) essential oil, lecithin, Leontopodium alpinum (edelweiss)extract, leuconostoc/radish root ferment (leucidal), linoleic acid,magnesium ascorbyl phosphate, magnesium chloride, matrix peptides, mixedtocopherols (vitamin E), Morus alba (mulberry) root extract,niacinamide, noni, non-nano zinc oxide, oat beta glucans, Oenotherabiennis (evening primrose) oil, oleic acid, omega 6 fatty acids, omega 9fatty acids, omega-3 fatty acids, Oryza sativa (rice) bran oil,palmitic, palmitoyl tripeptide-5, Passiflora incarnate (passion fruit)oil, pearl powder, Persea gratissima (avocado) oil, phytosphingosine,Pinus densiflora (red pine needle) oil, Plantago species (plantain) leafextract, Polianthes tuberosa (tuberose) essential oil, polyaminopropylbiguanide (cosmocil CQ), polyglucose/lactylate, Populus tremuloides(aspen) bark extract, potassium sorbate, Prunus armeniaca (apricot)kernel oil, pullulan, red pond algae, red raspberry seed oil,resveratrol, retinyl palmitate (retinol), Rosa centifolia (rose)essential oil, Rosa rubignosa (rosehip) seed oil, Rosmarinus officinalis(rosemary) oleoresin, Rubus idaeus (red raspberry) seed oil,saccharomyces ferment, Salvia hispanica (chia) seed oil, Sclerocaryabirrea (marula) oil, sea kelp extract, Sesamum indicum (sesame seed)oil, Simmondsia chinensis (jojoba) oil, SOD, sodium alginate, sodiumbenzoate, sodium hyaluronate, sodium lauroyl lactylate, soy peptides,soy-rice peptides [oxidoreductase], squalene, sucrose cocoate, sugarmulse [cetearyl alcohol], Tamarindus indica (tamarind) seed extract,teprenone, thioctic (alpha lipoic) acid, Trachelospermum jasminoides(star jasmine) essential oil, tripeptide-29, tripeptides, ubidecarenone,undecylenoyl phenylalanine, vitamin A, vitamin C, Vitus viniferi(grapeseed) oil, watermelon seed oil, white tea extract, xanthan gum,and xylitum black tea ferment (kombucha) extract.

Species of Abalone—Haliotis

Haliotis albicans, Haliotis aleata, Haliotis alfredensis, Haliotisalternata, Haliotis ancile, Haliotis aquatilis, Haliotis asinina,Haliotis asinum, Haliotis assimilis, Haliotis astricta, Haliotis aulaea,Haliotis aurantium, Haliotis australis, Haliotis barbouri, Haliotisbonita, Haliotis brazieri, Haliotis brazieri hargravesi, Haliotiscaelata, Haliotis californiana, Haliotis californiensis, Haliotiscanaliculata, Haliotis canariensis, Haliotis capensis, Haliotiscarinata, Haliotis cingulata, Haliotis clathrata, Haliotis coccinea,Haliotis coccoradiata, Haliotis concinna, Haliotis conicopora, Haliotiscorrugata, Haliotis corrugata corrugata, Haliotis corrugata oweni,Haliotis costata, Haliotis cracherodii, Haliotis cracherodiicaliforniensis, Haliotis cracherodii cracherodii, Haliotiscrebrisculpta, Haliotis crenata, Haliotis cruenta, Haliotis cunninghami,Haliotis cyclobates, Haliotis dalli, Haliotis dalli dalli, Haliotisdalli roberti, Haliotis dentata, Haliotis desussata, Haliotisdiegoensis, Haliotis discus, Haliotis discus discus, Haliotis discushannai, Haliotis dissona, Haliotis diversicolor, Haliotis diversicolordiversicolor, Haliotis diversicolor squamata, Haliotis diversicolorsupertexta, Haliotis dohrniana, Haliotis dringii, Haliotis drogini,Haliotis echinata, Haliotis elatior, Haliotis elegans, Haliotis elevata,Haliotis ethologus, Haliotis excavata, Haliotis exigua, Haliotisexpansa, Haliotis fatui, Haliotis ficiformis, Haliotis fulgens, Haliotisfulgens fulgens, Haliotis fulgens guadalupensis, Haliotis fulgensturveri, Haliotis fulgens walallensis, Haliotis funebris, Haliotisgemma, Haliotis gibba, Haliotis gigantea, Haliotis gigas, Haliotisglabra, Haliotis granti, Haliotis granulata, Haliotis grayana, Haliotisgruneri, Haliotis guadalupensis, Haliotis guineensis, Haliotis hanleyi,Haliotis hargravesi, Haliotis hattorii, Haliotis holzneri, Haliotishowensis, Haliotis imperforata, Haliotis improbula, Haliotis incisa,Haliotis iris, Haliotis jacnensis, Haliotis jacnensis jacnensis,Haliotis janus, Haliotis japonica, Haliotis jousseaumi, Haliotiskamtschatkana, Haliotis kamtschatkana assimilis, Haliotis kamtschatkanakamtschatkana, Haliotis kraussi, Haliotis laevigata, Haliotis lamellosa,Haliotis latilabris, Haliotis lauta, Haliotis lucida, Haliotis lusus,Haliotis madaka, Haliotis marfaloni, Haliotis mariae, Haliotismarmorata, Haliotis melculus, Haliotis midae, Haliotis multiperforata,Haliotis mykonosensis, Haliotis naevosa, Haliotis nebulata, Haliotisneglecta, Haliotis nodosa, Haliotis ovina, Haliotis ovina ovina,Haliotis ovina volcanius, Haliotis oweni, Haliotis papulata, Haliotisparva, Haliotis patamakanthini, Haliotis pellucida, Haliotis pertusa,Haliotis picta, Haliotis planata, Haliotis planilirata, Haliotisponderosa, Haliotis pourtalesii, Haliotis pourtalesii aurantium,Haliotis pourtalesii pourtalesii, Haliotis pulcherrima, Haliotispustulata, Haliotis pustulifera, Haliotis queketti, Haliotis reticulata,Haliotis revelata, Haliotis roberti, Haliotis roedingi, Haliotis roei,Haliotis rosacea, Haliotis rosea, Haliotis ruber, Haliotis rubicunda,Haliotis rubiginosa, Haliotis rubra, Haliotis rubra conicopora, Haliotisrubra rubra, Haliotis rufescens, Haliotis rugosa, Haliotisrugosoplicata, Haliotis sanguinea, Haliotis scabricostata, Haliotisscalaris, Haliotis scalaris scalaris, Haliotis scutulum, Haliotissemiplicata, Haliotis semistriata, Haliotis sieboldii, Haliotis sinuata,Haliotis smithsoni, Haliotis sorenseni, Haliotis spadicea, Haliotissplendens, Haliotis splendidula, Haliotis squamata, Haliotis squamosa,Haliotis stomatiaeformis, Haliotis striata, Haliotis strigata, Haliotissubvirginea, Haliotis sulcosa, Haliotis supertexta, Haliotis tayloriana,Haliotis thailandis, Haliotis tomricei, Haliotis tricostalis, Haliotistricostata, Haliotis tuberculata, Haliotis tuberculata coccinea,Haliotis tuberculata tuberculata, Haliotis tubifera, Haliotis turveri,Haliotis tuvuthaensis, Haliotis unilateralis, Haliotis varia, Haliotisvaria dohrniana, Haliotis varia planata, Haliotis venusta, Haliotisvirginea, Haliotis virginea virginea, Haliotis viridis, Haliotisvixlirata, Haliotis volcanius, Haliotis vulgaris, Haliotis walallensis,Haliotis whitehousei, Haliotis zealandica, and Haliotis ziczac.

Embodiments

In one embodiment of the disclosed extraction method the tissue is thevisceral mass. In one embodiment of the disclosed extraction method thetissue is the conical appendage. In one embodiment of the disclosedextraction method the tissue is the digestive gland. In one embodimentof the disclosed extraction method the tissue is the testes. In oneembodiment of the disclosed extraction method the tissue is the ovary.In one embodiment of the disclosed extraction method the tissue is thewhole organism.

Abalone

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis spp. In oneembodiment of the disclosed composition, the composition comprises from10% to 100% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis spp. In one embodiment of thedisclosed composition, the composition comprises from 20% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis spp. In one embodiment of the disclosedcomposition, the composition comprises from 35% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofHaliotis spp. In one embodiment of the disclosed composition, thecomposition comprises from 35% to 80% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotis spp. Inone embodiment of the disclosed composition, the composition comprisesfrom 35% to 60% of a whole body extract, visceral extract, conicalappendage extract, digestive gland extract, testes extract, ovaryextract or combination of extracts of Haliotis spp. In one embodiment ofthe disclosed composition, the composition comprises from 20% to 50% ofa whole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis spp.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis fulgens. In oneembodiment of the disclosed composition, the composition comprises from10% to 100% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis fulgens. In one embodiment of thedisclosed composition, the composition comprises from 20% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis fulgens. In one embodiment of the disclosedcomposition, the composition comprises from 35% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofHaliotis fulgens. In one embodiment of the disclosed composition, thecomposition comprises from 35% to 80% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotis fulgens.In one embodiment of the disclosed composition, the compositioncomprises from 35% to 60% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis fulgens. In oneembodiment of the disclosed composition, the composition comprises from20% to 50% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis fulgens.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis rufescens. In oneembodiment of the disclosed composition, the composition comprises from10% to 100% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis rufescens. In one embodiment of thedisclosed composition, the composition comprises from 20% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis rufescens. In one embodiment of the disclosedcomposition, the composition comprises from 35% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofHaliotis rufescens. In one embodiment of the disclosed composition, thecomposition comprises from 35% to 80% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotis rufescens.In one embodiment of the disclosed composition, the compositioncomprises from 35% to 60% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis rufescens. In oneembodiment of the disclosed composition, the composition comprises from20% to 50% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis rufescens.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis corrugata. In oneembodiment of the disclosed composition, the composition comprises from10% to 100% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis corrugata. In one embodiment of thedisclosed composition, the composition comprises from 20% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis corrugata. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 80% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofHaliotis corrugata. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 60% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotis corrugata.In one embodiment of the disclosed composition, the compositioncomprises from 20% to 55% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis corrugata.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis kamtschatkana. Inone embodiment of the disclosed composition, the composition comprisesfrom 20% to 100% of a whole body extract, visceral extract, conicalappendage extract, digestive gland extract, testes extract, ovaryextract or combination of extracts of Haliotis kamtschatkana. In oneembodiment of the disclosed composition, the composition comprises from40% to 100% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis kamtschatkana. In one embodiment ofthe disclosed composition, the composition comprises from 60% to 100% ofa whole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis kamtschatkana. In one embodiment of the disclosedcomposition, the composition comprises from 10% to 80% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofHaliotis kamtschatkana. In one embodiment of the disclosed composition,the composition comprises from 10% to 60% of a whole body extract,visceral extract, conical appendage extract, digestive gland extract,testes extract, ovary extract or combination of extracts of Haliotiskamtschatkana. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 40% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotiskamtschatkana. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 30% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotiskamtschatkana.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of Haliotis walallensis. In oneembodiment of the disclosed composition, the composition comprises from10% to 100% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of Haliotis walallensis. In one embodiment ofthe disclosed composition, the composition comprises from 20% to 100% ofa whole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of Haliotis walallensis. In one embodiment of the disclosedcomposition, the composition comprises from 40% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofHaliotis walallensis. In one embodiment of the disclosed composition,the composition comprises from 20% to 60% of a whole body extract,visceral extract, conical appendage extract, digestive gland extract,testes extract, ovary extract or combination of extracts of Haliotiswalallensis. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 80% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotiswalallensis. In one embodiment of the disclosed composition, thecomposition comprises from 40% to 60% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of Haliotiswalallensis.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of hybrid Haliotis rufescens xHaliotis corrugata. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 100% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis corrugata. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofhybrid Haliotis rufescens x Haliotis corrugata. In one embodiment of thedisclosed composition, the composition comprises from 40% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of hybrid Haliotis rufescens Haliotis corrugata. In oneembodiment of the disclosed composition, the composition comprises from10% to 80% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of hybrid Haliotis rufescens x Haliotiscorrugata. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 60% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis corrugata. In one embodiment of the disclosedcomposition, the composition comprises from 10% to 50% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofhybrid Haliotis rufescens x Haliotis corrugata.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of hybrid Haliotis rufescens xHaliotis fulgens. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 100% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis fulgens. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofhybrid Haliotis rufescens x Haliotis fulgens. In one embodiment of thedisclosed composition, the composition comprises from 40% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of hybrid Haliotis rufescens x Haliotis fulgens. In oneembodiment of the disclosed composition, the composition comprises from10% to 80% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of hybrid Haliotis rufescens x Haliotis fulgens.In one embodiment of the disclosed composition, the compositioncomprises from 10% to 60% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of hybrid Haliotis rufescens xHaliotis fulgens. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 50% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis fulgens.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,conical appendage extract, digestive gland extract, testes extract,ovary extract or combination of extracts of hybrid Haliotis rufescens xHaliotis laevagata. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 100% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis laevagata. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 100% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofhybrid Haliotis rufescens x Haliotis laevagata. In one embodiment of thedisclosed composition, the composition comprises from 40% to 100% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of hybrid Haliotis rufescens x Haliotis laevagata. In oneembodiment of the disclosed composition, the composition comprises from10% to 80% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of hybrid Haliotis rufescens x Haliotislaevagata. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 60% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis laevagata. In one embodiment of the disclosedcomposition, the composition comprises from 10% to 50% of a whole bodyextract, visceral extract, conical appendage extract, digestive glandextract, testes extract, ovary extract or combination of extracts ofhybrid Haliotis rufescens x Haliotis laevagata. In one embodiment of thedisclosed composition, the composition comprises from 25% to 60% of awhole body extract, visceral extract, conical appendage extract,digestive gland extract, testes extract, ovary extract or combination ofextracts of hybrid Haliotis rufescens x Haliotis laevagata. In oneembodiment of the disclosed composition, the composition comprises from25% to 80% of a whole body extract, visceral extract, conical appendageextract, digestive gland extract, testes extract, ovary extract orcombination of extracts of hybrid Haliotis rufescens x Haliotislaevagata. In one embodiment of the disclosed composition, thecomposition comprises from 25% to 100% of a whole body extract, visceralextract, conical appendage extract, digestive gland extract, testesextract, ovary extract or combination of extracts of hybrid Haliotisrufescens x Haliotis laevagata.

Algae

Algae and seaweed peptides speed healing by promoting cell growth,nourishing the skin with vitamins and minerals and enhancing barrierfunction.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Macrocystis integrifolia. Inone embodiment of the disclosed composition, the composition comprisesfrom 1% to 80% of an extract of Macrocystis integrifolia. In oneembodiment of the disclosed composition, the composition comprises from1% to 60% of an extract of Macrocystis integrifolia. In one embodimentof the disclosed composition, the composition comprises from 1% to 40%of an extract of Macrocystis integrifolia. In one embodiment of thedisclosed composition, the composition comprises from 10% to 80% of anextract of Macrocystis integrifolia. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 60% of an extract ofMacrocystis integrifolia. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 40% of an extract ofMacrocystis integrifolia.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Macrocystis pyrifera. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Macrocystis pyrifera. In one embodiment ofthe disclosed composition, the composition comprises from 1% to 40% ofan extract of Macrocystis pyrifera. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 20% of an extract ofMacrocystis pyrifera. In one embodiment of the disclosed composition,the composition comprises from 1% to 15% of an extract of Macrocystispyrifera. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 15% of an extract of Macrocystispyrifera. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 40% of an extract of Macrocystispyrifera. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 60% of an extract of Macrocystispyrifera.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Fucus vesiculosis. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Fucus vesiculosis. In one embodiment of thedisclosed composition, the composition comprises from 1% to 50% of anextract of Fucus vesiculosis. In one embodiment of the disclosedcomposition, the composition comprises from 10% to 100% of an extract ofFucus vesiculosis. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 80% of an extract of Fucusvesiculosis. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 60% of an extract of Fucusvesiculosis. In one embodiment of the disclosed composition, thecomposition comprises from 40% to 50% of an extract of Fucusvesiculosis.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Ascophyllum nodosum. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Ascophyllum nodosum. In one embodiment of thedisclosed composition, the composition comprises from 1% to 60% of anextract of Ascophyllum nodosum. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 40% of an extract ofAscophyllum nodosum. In one embodiment of the disclosed composition, thecomposition comprises from 1% to 20% of an extract of Ascophyllumnodosum. In one embodiment of the disclosed composition, the compositioncomprises from 1% to 10% of an extract of Ascophyllum nodosum. In oneembodiment of the disclosed composition, the composition comprises from5% to 10% of an extract of Ascophyllum nodosum. In one embodiment of thedisclosed composition, the composition comprises from 10% to 80% of anextract of Ascophyllum nodosum. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 60% of an extract ofAscophyllum nodosum. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 50% of an extract of Ascophyllumnodosum.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Spirulina pacifica. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Spirulina pacifica. In one embodiment of thedisclosed composition, the composition comprises from 5% to 100% of anextract of Spirulina pacifica. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 85% of an extract ofSpirulina pacifica. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 65% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 50% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 80% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 60% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 50% of an extract of Spirulinapacifica.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Sargassum muticum. In oneembodiment of the disclosed composition, the composition comprises from1% to 75% of an extract of Sargassum muticum. In one embodiment of thedisclosed composition, the composition comprises from 1% to 50% of anextract of Sargassum muticum. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 25% of an extract ofSargassum muticum. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 25% of an extract of Sargassum muticum.In one embodiment of the disclosed composition, the compositioncomprises from 10% to 50% of an extract of Sargassum muticum. In oneembodiment of the disclosed composition, the composition comprises from20% to 60% of an extract of Sargassum muticum. In one embodiment of thedisclosed composition, the composition comprises from 40% to 50% of anextract of Sargassum muticum. In one embodiment of the disclosedcomposition, the composition comprises from 25% to 75% of an extract ofSargassum muticum.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Chlorella pyrenoidosa. In oneembodiment of the disclosed composition, the composition comprises from5% to 80% of an extract of Chlorella pyrenoidosa. In one embodiment ofthe disclosed composition, the composition comprises from 5% to 60% ofan extract of Chlorella pyrenoidosa. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 40% of an extract ofChlorella pyrenoidosa. In one embodiment of the disclosed composition,the composition comprises from 10% to 80% of an extract of Chlorellapyrenoidosa. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 60% of an extract of Chlorellapyrenoidosa. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 50% of an extract of Chlorellapyrenoidosa.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Chlorella variabilis. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Chlorella variabilis. In one embodiment ofthe disclosed composition, the composition comprises from 1% to 60% ofan extract of Chlorella variabilis. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 20% of an extract ofChlorella variabilis. In one embodiment of the disclosed composition,the composition comprises from 5% to 30% of an extract of Chlorellavariabilis. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 50% of an extract of Chlorellavariabilis. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 80% of an extract of Chlorellavariabilis. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 60% of an extract of Chlorellavariabilis. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 50% of an extract of Chlorellavariabilis.

Cyanobacteria

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Spirulina pacifica. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Spirulina pacifica. In one embodiment of thedisclosed composition, the composition comprises from 1% to 60% of anextract of Spirulina pacifica. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 100% of an extract ofSpirulina pacifica. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 85% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 60% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 80% of an extract of Spirulinapacifica. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 60% of an extract of Spirulinapacifica.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Arthrospira maxima. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Arthrospira maxima. In one embodiment of thedisclosed composition, the composition comprises from 1% to 60% of anextract of Arthrospira maxima. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 25% of an extract ofArthrospira maxima. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 50% of an extract of Arthrospiramaxima. In one embodiment of the disclosed composition, the compositioncomprises from 5% to 75% of an extract of Arthrospira maxima. In oneembodiment of the disclosed composition, the composition comprises from10% to 80% of an extract of Arthrospira maxima. In one embodiment of thedisclosed composition, the composition comprises from 20% to 60% of anextract of Arthrospira maxima. In one embodiment of the disclosedcomposition, the composition comprises from 30% to 50% of an extract ofArthrospira maxima.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Arthrospira planensis. In oneembodiment of the disclosed composition, the composition comprises from1% to 80% of an extract of Arthrospira planensis. In one embodiment ofthe disclosed composition, the composition comprises from 3% to 60% ofan extract of Arthrospira planensis. In one embodiment of the disclosedcomposition, the composition comprises from 3% to 30% of an extract ofArthrospira planensis. In one embodiment of the disclosed composition,the composition comprises from 5% to 80% of an extract of Arthrospiraplanensis. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 60% of an extract of Arthrospiraplanensis. In one embodiment of the disclosed composition, thecomposition comprises from 20% to 50% of an extract of Arthrospiraplanensis.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Microcystis aeruginosa. Inone embodiment of the disclosed composition, the composition comprisesfrom 1% to 80% of an extract of Microcystis aeruginosa. In oneembodiment of the disclosed composition, the composition comprises from1% to 50% of an extract of Microcystis aeruginosa. In one embodiment ofthe disclosed composition, the composition comprises from 1% to 30% ofan extract of Microcystis aeruginosa. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 20% of an extract ofMicrocystis aeruginosa. In one embodiment of the disclosed composition,the composition comprises from 1% to 10% of an extract of Microcystisaeruginosa. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 10% of an extract of Microcystisaeruginosa. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 20% of an extract of Microcystisaeruginosa. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 30% of an extract of Microcystisaeruginosa.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of an extract of Microcystis wesenbergii. Inone embodiment of the disclosed composition, the composition comprisesfrom 1% to 60% of an extract of Microcystis wesenbergii. In oneembodiment of the disclosed composition, the composition comprises from1% to 40% of an extract of Microcystis wesenbergii. In one embodiment ofthe disclosed composition, the composition comprises from 1% to 20% ofan extract of Microcystis wesenbergii. In one embodiment of thedisclosed composition, the composition comprises from 5% to 20% of anextract of Microcystis wesenbergii. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 15% of an extract ofMicrocystis wesenbergii. In one embodiment of the disclosed composition,the composition comprises from 5% to 10% of an extract of Microcystiswesenbergii.

Bivalves

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Chlamys rubida. In one embodiment of the disclosed composition, thecomposition comprises from 1% to 80% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Chlamys rubida. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 60% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Chlamys rubida. In one embodiment of thedisclosed composition, the composition comprises from 1% to 40% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Chlamys rubida. In oneembodiment of the disclosed composition, the composition comprises from5% to 40% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Chlamysrubida. In one embodiment of the disclosed composition, the compositioncomprises from 10% to 40% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Chlamys rubida. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 80% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Chlamys rubida. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 60% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Chlamys rubida.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Chlamys hastate. In one embodiment of the disclosed composition, thecomposition comprises from 1% to 60% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Chlamys hastate. In one embodiment of the disclosedcomposition, the composition comprises from 3% to 40% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Chlamys hastate. In one embodiment of thedisclosed composition, the composition comprises from 3% to 20% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Chlamys hastate. In oneembodiment of the disclosed composition, the composition comprises from5% to 20% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Chlamyshastate. In one embodiment of the disclosed composition, the compositioncomprises from 10% to 20% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Chlamys hastate. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 40% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Chlamys hastate. In one embodiment of the disclosedcomposition, the composition comprises from 10% to 60% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Chlamys hastate. In one embodiment of thedisclosed composition, the composition comprises from 20% to 40% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Chlamys hastate. In oneembodiment of the disclosed composition, the composition comprises from30% to 50% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Chlamyshastate.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Crassotrea gigas. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 80% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Crassotrea gigas. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 60% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea gigas. In one embodiment of thedisclosed composition, the composition comprises from 5% to 50% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Crassotrea gigas. In oneembodiment of the disclosed composition, the composition comprises from10% to 50% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Crassotreagigas. In one embodiment of the disclosed composition, the compositioncomprises from 20% to 50% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Crassotrea gigas. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 50% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Crassotrea gigas. In one embodiment of the disclosedcomposition, the composition comprises from 40% to 50% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea gigas.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Crassotrea corteziensis. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 80% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea corteziensis. In one embodimentof the disclosed composition, the composition comprises from 10% to 50%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Crassotreacorteziensis. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 30% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Crassotrea corteziensis. In one embodiment of the disclosedcomposition, the composition comprises from 3% to 15% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea corteziensis. In one embodimentof the disclosed composition, the composition comprises from 5% to 15%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Crassotreacorteziensis. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 15% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Crassotrea corteziensis.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Crassotrea columbiensis. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 80% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea columbiensis. In one embodimentof the disclosed composition, the composition comprises from 1% to 60%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Crassotreacolumbiensis. In one embodiment of the disclosed composition, thecomposition comprises from 1% to 40% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Crassotrea columbiensis. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 20% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea columbiensis. In one embodimentof the disclosed composition, the composition comprises from 5% to 10%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Crassotreacolumbiensis. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 30% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Crassotrea columbiensis. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 50% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Crassotrea columbiensis.

Sea Cucumbers

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Holothuria mexicana. In one embodiment of the disclosed composition,the composition comprises from 10% to 100% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Holothuria mexicana. In one embodiment of thedisclosed composition, the composition comprises from 20% to 100% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Holothuria mexicana. In oneembodiment of the disclosed composition, the composition comprises from40% to 100% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Holothuriamexicana. In one embodiment of the disclosed composition, thecomposition comprises from 60% to 100% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Holothuria mexicana. In one embodiment of the disclosedcomposition, the composition comprises from 80% to 100% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Holothuria mexicana. In one embodiment ofthe disclosed composition, the composition comprises from 20% to 80% ofa whole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Holothuria mexicana. In oneembodiment of the disclosed composition, the composition comprises from30% to 60% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Holothuriamexicana. In one embodiment of the disclosed composition, thecomposition comprises from 40% to 50% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Holothuria mexicana.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Holothuria californicus. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 80% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Holothuria californicus. In one embodimentof the disclosed composition, the composition comprises from 10% to 60%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Holothuriacalifornicus. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 40% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Holothuria californicus. In one embodiment of the disclosedcomposition, the composition comprises from 15% to 40% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Holothuria californicus. In one embodimentof the disclosed composition, the composition comprises from 20% to 40%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Holothuriacalifornicus. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 40% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Holothuria californicus. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 80% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Holothuria californicus. In one embodimentof the disclosed composition, the composition comprises from 30% to 60%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Holothuriacalifornicus. In one embodiment of the disclosed composition, thecomposition comprises from 40% to 50% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Holothuria californicus.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Holothuria scabra. In one embodiment of the disclosed composition,the composition comprises from 1% to 80% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Holothuria scabra. In one embodiment of thedisclosed composition, the composition comprises from 5% to 60% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Holothuria scabra. In oneembodiment of the disclosed composition, the composition comprises from10% to 60% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Holothuriascabra. In one embodiment of the disclosed composition, the compositioncomprises from 10% to 40% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Holothuria scabra. In one embodiment of the disclosed composition,the composition comprises from 10% to 20% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Holothuria scabra. In one embodiment of thedisclosed composition, the composition comprises from 20% to 50% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Holothuria scabra. In oneembodiment of the disclosed composition, the composition comprises from30% to 60% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Holothuriascabra.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Stichopus chlorontus. In one embodiment of the disclosed composition,the composition comprises from 1% to 80% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Stichopus chlorontus. In one embodiment ofthe disclosed composition, the composition comprises from 5% to 60% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Stichopus chlorontus. In oneembodiment of the disclosed composition, the composition comprises from5% to 50% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Stichopuschlorontus. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 50% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Stichopus chlorontus. In one embodiment of the disclosedcomposition, the composition comprises from 20% to 50% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Stichopus chlorontus. In one embodiment ofthe disclosed composition, the composition comprises from 30% to 50% ofa whole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Stichopus chlorontus. In oneembodiment of the disclosed composition, the composition comprises from40% to 50% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Stichopuschlorontus.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Stichopus horrens. In one embodiment of the disclosed composition,the composition comprises from 1% to 80% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Stichopus horrens. In one embodiment of thedisclosed composition, the composition comprises from 1% to 60% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Stichopus horrens. In oneembodiment of the disclosed composition, the composition comprises from5% to 50% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Stichopushorrens. In one embodiment of the disclosed composition, the compositioncomprises from 5% to 40% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Stichopus horrens. In one embodiment of the disclosed composition,the composition comprises from 5% to 35% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Stichopus horrens. In one embodiment of thedisclosed composition, the composition comprises from 10% to 35% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Stichopus horrens. In oneembodiment of the disclosed composition, the composition comprises from15% to 35% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Stichopushorrens. In one embodiment of the disclosed composition, the compositioncomprises from 20% to 35% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Stichopus horrens.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Stichopus japonicus. In one embodiment of the disclosed composition,the composition comprises from 1% to 80% of a whole body extract,visceral extract, gonad extract, testes extract, ovary extract orcombination of extracts of Stichopus japonicus. In one embodiment of thedisclosed composition, the composition comprises from 5% to 60% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Stichopus japonicus. In oneembodiment of the disclosed composition, the composition comprises from5% to 40% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Stichopusjaponicus. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 25% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Stichopus japonicus. In one embodiment of the disclosedcomposition, the composition comprises from 10% to 25% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Stichopus japonicus. In one embodiment ofthe disclosed composition, the composition comprises from 15% to 25% ofa whole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Stichopus japonicus.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Apostichopus japonicus. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 80% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Apostichopus japonicus. In one embodimentof the disclosed composition, the composition comprises from 5% to 60%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Apostichopusjaponicus. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 40% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Apostichopus japonicus. In one embodiment of the disclosedcomposition, the composition comprises from 5% to 25% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Apostichopus japonicus. In one embodimentof the disclosed composition, the composition comprises from 10% to 25%of a whole body extract, visceral extract, gonad extract, testesextract, ovary extract or combination of extracts of Apostichopusjaponicus. In one embodiment of the disclosed composition, thecomposition comprises from 15% to 25% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Apostichopus japonicus.

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsa visceral extract of Cucumaria japonica. In one embodiment of thedisclosed composition, the composition comprises from 1% to 80% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts a visceral extract of Cucumariajaponica. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 60% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts a visceral extract of Cucumaria japonica. In one embodiment ofthe disclosed composition, the composition comprises from 10% to 60% ofa whole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts a visceral extract of Cucumariajaponica. In one embodiment of the disclosed composition, thecomposition comprises from 15% to 60% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts a visceral extract of Cucumaria japonica. In one embodiment ofthe disclosed composition, the composition comprises from 25% to 60% ofa whole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts a visceral extract of Cucumariajaponica. In one embodiment of the disclosed composition, thecomposition comprises from 30% to 50% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts a visceral extract of Cucumaria japonica. In one embodiment ofthe disclosed composition, the composition comprises from 20% to 40% ofa whole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts a visceral extract of Cucumariajaponica. In one embodiment of the disclosed composition, thecomposition comprises from 15% to 30% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts a visceral extract of Cucumaria japonica.

Crustaceans

In one embodiment of the disclosed composition, the compositioncomprises from 1% to 100% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Paralothodes camtschaticus. In one embodiment of the disclosedcomposition, the composition comprises from 1% to 80% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Paralothodes camtschaticus. In oneembodiment of the disclosed composition, the composition comprises from5% to 60% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Paralothodescamtschaticus. In one embodiment of the disclosed composition, thecomposition comprises from 5% to 50% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Paralothodes camtschaticus. In one embodiment of thedisclosed composition, the composition comprises from 10% to 50% of awhole body extract, visceral extract, gonad extract, testes extract,ovary extract or combination of extracts of Paralothodes camtschaticus.In one embodiment of the disclosed composition, the compositioncomprises from 25% to 50% of a whole body extract, visceral extract,gonad extract, testes extract, ovary extract or combination of extractsof Paralothodes camtschaticus. In one embodiment of the disclosedcomposition, the composition comprises from 15% to 40% of a whole bodyextract, visceral extract, gonad extract, testes extract, ovary extractor combination of extracts of Paralothodes camtschaticus. In oneembodiment of the disclosed composition, the composition comprises from15% to 25% of a whole body extract, visceral extract, gonad extract,testes extract, ovary extract or combination of extracts of Paralothodescamtschaticus. In one embodiment of the disclosed composition, thecomposition comprises from 10% to 25% of a whole body extract, visceralextract, gonad extract, testes extract, ovary extract or combination ofextracts of Paralothodes camtschaticus.

Additional embodiments are described in the following paragraphs.

Paragraph 1. A composition comprising an abalone tissue extract.

Paragraph 2. The composition of Paragraph 1, wherein the abalone isHaliotis spp.

Paragraph 3. The composition of Paragraph 2, wherein the Haliotis spp.is selected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 4. The composition of Paragraph 1, wherein the abalone is ahybrid abalone.

Paragraph 5. The composition of Paragraph 4, wherein the hybrid abaloneis selected from the group consisting of Haliotis rufescens x Haliotiscorrugate, Haliotis rufescens x Haliotis fulgens, and Haliotis rufescensx Haliotis laevagata.

Paragraph 6. The composition of Paragraph 1, wherein the tissue isselected from the group consisting of at least one of muscle, viscera,conical appendage, digestive gland, gonad, testes and ovary.

Paragraph 7. The composition of Paragraph 1, further comprising anextract from a marine organism.

Paragraph 8. The composition of Paragraph 7, wherein the marine organismis selected from the group consisting of alga, bivalve, crustacean, seacucumber, and cyanobacteria.

Paragraph 9. The composition of Paragraph 8, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 10. The composition of Paragraph 8, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 11. The composition of Paragraph 8, wherein the crustacean isParalothodes camtschaticus.

Paragraph 12. The composition of Paragraph 8, wherein the sea cucumberis selected from the group consisting of Holothuria mexicana, Holothuriacalifornicus, Holothuria scabra, Stichopus chlorontus, Stichopushorrens, Stichopus japonicus, Apostichopus japonicus, and Cucumariajaponica.

Paragraph 13. The composition of Paragraph 8, wherein the cyanobacteriais selected from the group consisting of Spirulina pacifica, Arthrospiramaxima, Arthrospira planensis, Microcystis aeruginosa, and Microcystiswesenbergii.

Paragraph 14. The composition of Paragraph 1, further comprising acosmetic product.

Paragraph 15. The composition of Paragraph 14, wherein the cosmeticproduct is selected from the group consisting of one or more of acetylhexapeptide-3 (argirilene), acrylates/C₁₀₋₃₀ alkyl acrylatecross-polymer, Actinidia deliciosa (kiwi) seed oil, algae extract,Andropogon zizanioides (vetiver) essential oil, Aniba rosaeodora(rosewood) essential oil, apricot kernel oil, Arctostaphylos uva ursiextract, Argania spinosa (argan) oil, argirilene, astaxanthin, betaglucan, Borago officinalis (borage) oil, Boswellia carterii(frankincense) essential oil, Caesalpinia spinosa (tara) gum], calciumcarbonate, Camellia oleifera (camellia) oil, Camellia sinensis, Cannabissativa (hemp) seed oil, caprylic/capric triglyceride], Carica papaya(papaya) seed oil, cellulose gum, Centella asiatica (gotu kola) extract,ceramide 1, ceramide 3, ceramide 6 II, ceramide complex, cetearylglucoside, chitin, chitosan, cholecalciferol (vitamin D3), cholesterol,Citrullus lanatus (watermelon) extract, Citrus aurantium (neroli)hydrosol, Citrus paradisi (grapefruit) essential oil, Cocos nucifera(coconut) oil, coenzyme Q10, Crithmum maritimum (sea fennel) extract,decyl polyglucoside, dipeptide diaminobutyroyl benzylamide diacetate(snake peptides), elastin, Enteromorpha compressa extract, fatty acids,gamma-oryzanol, geranylgeranone gga, gluconolactone, glucosamine, glycanbooster [tetradecyl amino-butyroylvalyl-aminobutyric ureatrifluoro-acetate, glycerin, Glycine soja (soybean) oil, glycoproteins,Glycyrrhiza glabra (licorice root) extract, green tea extract,Gynostemma pentaphyllum (gynostemma) extract, Haematococcus pulvialis,Helianthus annuus (sunflower) seed oil, homeostatine, hyaluronic acid,hydrolyzed rice bran extract, hydroquinone, lactoceramides, Lavendulaangustfolia (lavender) essential oil, lecithin, Leontopodium alpinum(edelweiss) extract, leuconostoc/radish root ferment (leucidal),linoleic acid, magnesium ascorbyl phosphate, magnesium chloride, matrixpeptides, mixed tocopherols (vitamin E), Morus alba (mulberry) rootextract, niacinamide, noni, non-nano zinc oxide, oat beta glucans,Oenothera biennis (evening primrose) oil, oleic acid, omega 6 fattyacids, omega 9 fatty acids, omega-3 fatty acids, Oryza sativa (rice)bran oil, palmitic, palmitoyl tripeptide-5, Passiflora incarnate(passion fruit) oil, pearl powder, Persea gratissima (avocado) oil,phytosphingosine, Pinus densiflora (red pine needle) oil, Plantagospecies (plantain) leaf extract, Polianthes tuberosa (tuberose)essential oil, polyaminopropyl biguanide (cosmocil CQ),polyglucose/lactylate, Populus tremuloides (aspen) bark extract,potassium sorbate, Prunus armeniaca (apricot) kernel oil, pullulan, redpond algae, red raspberry seed oil, resveratrol, retinyl palmitate(retinol), Rosa centifolia (rose) essential oil, Rosa rubignosa(rosehip) seed oil, Rosmarinus officinalis (rosemary) oleoresin, Rubusidaeus (red raspberry) seed oil, saccharomyces ferment, Salvia hispanica(chia) seed oil, Sclerocarya birrea (marula) oil, sea kelp extract,Sesamum indicum (sesame seed) oil, Simmondsia chinensis (jojoba) oil,SOD, sodium alginate, sodium benzoate, sodium hyaluronate, sodiumlauroyl lactylate, soy peptides, soy-rice peptides [oxidoreductase],squalene, sucrose cocoate, sugar mulse [cetearyl alcohol], Tamarindusindica (tamarind) seed extract, teprenone, thioctic (alpha lipoic) acid,Trachelospermum jasminoides (star jasmine) essential oil, tripeptide-29,tripeptides, ubidecarenone, undecylenoyl phenylalanine, vitamin A,vitamin C, Vitus viniferi (grapeseed) oil, watermelon seed oil, whitetea extract, xanthan gum, and xylitum black tea ferment (kombucha)extract.

Paragraph 16. A composition comprising an alga tissue extract.

Paragraph 17. The composition of Paragraph 16, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 18. The composition of Paragraph 16, wherein the tissue isselected from the group consisting of at least one of frond and wholebody.

Paragraph 19. The composition of Paragraph 16, further comprising anextract from a marine organism.

Paragraph 20. The composition of Paragraph 19, wherein the marineorganism is selected from the group consisting of abalone, bivalve,crustacean, sea cucumber, and cyanobacteria.

Paragraph 21. The composition of Paragraph 20, wherein the abalone isHaliotis spp.

Paragraph 22. The composition of Paragraph 21, wherein the Haliotis spp.is selected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 23. The composition of Paragraph 20, wherein the abalone is ahybrid abalone.

Paragraph 24. The composition of Paragraph 23, wherein the hybridabalone is selected from the group consisting of Haliotis rufescens xHaliotis corrugate, Haliotis rufescens x Haliotis fulgens, and Haliotisrufescens x Haliotis laevagata.

Paragraph 25. The composition of Paragraph 20, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 26. The composition of Paragraph 20, wherein the crustacean isParalothodes camtschaticus.

Paragraph 27. The composition of Paragraph 20, wherein the sea cucumberis selected from the group consisting of Holothuria mexicana, Holothuriacalifornicus, Holothuria scabra, Stichopus chlorontus, Stichopushorrens, Stichopus japonicus, Apostichopus japonicus, and Cucumariajaponica.

Paragraph 28. The composition of Paragraph 20, wherein the cyanobacteriais selected from the group consisting of Spirulina pacifica, Arthrospiramaxima, Arthrospira planensis, Microcystis aeruginosa, and Microcystiswesenbergii.

Paragraph 29. The composition of Paragraph 16, further comprising acosmetic product.

Paragraph 30. The composition of Paragraph 29, wherein the cosmeticproduct is selected from the group consisting of one or more of acetylhexapeptide-3 (argirilene), acrylates/C₁₀₋₃₀ alkyl acrylatecross-polymer, Actinidia deliciosa (kiwi) seed oil, algae extract,Andropogon zizanioides (vetiver) essential oil, Aniba rosaeodora(rosewood) essential oil, apricot kernel oil, Arctostaphylos uva ursiextract, Argania spinosa (argan) oil, argirilene, astaxanthin, betaglucan, Borago officinalis (borage) oil, Boswellia carterii(frankincense) essential oil, Caesalpinia spinosa (tara) gum], calciumcarbonate, Camellia oleifera (camellia) oil, Camellia sinensis, Cannabissativa (hemp) seed oil, caprylic/capric triglyceride], Carica papaya(papaya) seed oil, cellulose gum, Centella asiatica (gotu kola) extract,ceramide 1, ceramide 3, ceramide 6 II, ceramide complex, cetearylglucoside, chitin, chitosan, cholecalciferol (vitamin D3), cholesterol,Citrullus lanatus (watermelon) extract, Citrus aurantium (neroli)hydrosol, Citrus paradisi (grapefruit) essential oil, Cocos nucifera(coconut) oil, coenzyme Q10, Crithmum maritimum (sea fennel) extract,decyl polyglucoside, dipeptide diaminobutyroyl benzylamide diacetate(snake peptides), elastin, Enteromorpha compressa extract, fatty acids,gamma-oryzanol, geranylgeranone gga, gluconolactone, glucosamine, glycanbooster [tetradecyl amino-butyroylvalyl-aminobutyric ureatrifluoro-acetate, glycerin, Glycine soja (soybean) oil, glycoproteins,Glycyrrhiza glabra (licorice root) extract, green tea extract,Gynostemma pentaphyllum (gynostemma) extract, Haematococcus pulvialis,Helianthus annuus (sunflower) seed oil, homeostatine, hyaluronic acid,hydrolyzed rice bran extract, hydroquinone, lactoceramides, Lavendulaangustfolia (lavender) essential oil, lecithin, Leontopodium alpinum(edelweiss) extract, leuconostoc/radish root ferment (leucidal),linoleic acid, magnesium ascorbyl phosphate, magnesium chloride, matrixpeptides, mixed tocopherols (vitamin E), Morus alba (mulberry) rootextract, niacinamide, noni, non-nano zinc oxide, oat beta glucans,Oenothera biennis (evening primrose) oil, oleic acid, omega 6 fattyacids, omega 9 fatty acids, omega-3 fatty acids, Oryza sativa (rice)bran oil, palmitic, palmitoyl tripeptide-5, Passiflora incarnate(passion fruit) oil, pearl powder, Persea gratissima (avocado) oil,phytosphingosine, Pinus densiflora (red pine needle) oil, Plantagospecies (plantain) leaf extract, Polianthes tuberosa (tuberose)essential oil, polyaminopropyl biguanide (cosmocil CQ),polyglucose/lactylate, Populus tremuloides (aspen) bark extract,potassium sorbate, Prunus armeniaca (apricot) kernel oil, pullulan, redpond algae, red raspberry seed oil, resveratrol, retinyl palmitate(retinol), Rosa centifolia (rose) essential oil, Rosa rubignosa(rosehip) seed oil, Rosmarinus officinalis (rosemary) oleoresin, Rubusidaeus (red raspberry) seed oil, saccharomyces ferment, Salvia hispanica(chia) seed oil, Sclerocarya birrea (marula) oil, sea kelp extract,Sesamum indicum (sesame seed) oil, Simmondsia chinensis (jojoba) oil,SOD, sodium alginate, sodium benzoate, sodium hyaluronate, sodiumlauroyl lactylate, soy peptides, soy-rice peptides [oxidoreductase],squalene, sucrose cocoate, sugar mulse [cetearyl alcohol], Tamarindusindica (tamarind) seed extract, teprenone, thioctic (alpha lipoic) acid,Trachelospermum jasminoides (star jasmine) essential oil, tripeptide-29,tripeptides, ubidecarenone, undecylenoyl phenylalanine, vitamin A,vitamin C, Vitus viniferi (grapeseed) oil, watermelon seed oil, whitetea extract, xanthan gum, and xylitum black tea ferment (kombucha)extract.

Paragraph 31. A composition comprising an bivalve tissue extract.

Paragraph 32. The composition of Paragraph 31, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 33. The composition of Paragraph 31, wherein the tissue isselected from the group consisting of at least one of adductor muscle,viscera, and gonad.

Paragraph 34. The composition of Paragraph 31, further comprising anextract from a marine organism.

Paragraph 35. The composition of Paragraph 34, wherein the marineorganism is selected from the group consisting of abalone alga,crustacean, sea cucumber, and cyanobacteria.

Paragraph 36. The composition of Paragraph 35, wherein the abalone isHaliotis spp.

Paragraph 37. The composition of Paragraph 36, wherein the Haliotis spp.is selected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 38. The composition of Paragraph 35, wherein the abalone is ahybrid abalone.

Paragraph 39. The composition of Paragraph 38, wherein the hybridabalone is selected from the group consisting of Haliotis rufescens xHaliotis corrugate, Haliotis rufescens x Haliotis fulgens, and Haliotisrufescens x Haliotis laevagata.

Paragraph 40. The composition of Paragraph 35, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 41. The composition of Paragraph 35, wherein the crustacean isParalothodes camtschaticus.

Paragraph 42. The composition of Paragraph 35, wherein the sea cucumberis selected from the group consisting of Holothuria mexicana, Holothuriacalifornicus, Holothuria scabra, Stichopus chlorontus, Stichopushorrens, Stichopus japonicus, Apostichopus japonicus, and Cucumariajaponica.

Paragraph 43. The composition of Paragraph 35, wherein the cyanobacteriais selected from the group consisting of Spirulina pacifica, Arthrospiramaxima, Arthrospira planensis, Microcystis aeruginosa, and Microcystiswesenbergii.

Paragraph 44. The composition of Paragraph 31, further comprising acosmetic product.

Paragraph 45. The composition of Paragraph 44, wherein the cosmeticproduct is selected from the group consisting of one or more of acetylhexapeptide-3 (argirilene), acrylates/C₁₀₋₃₀ alkyl acrylatecross-polymer, Actinidia deliciosa (kiwi) seed oil, algae extract,Andropogon zizanioides (vetiver) essential oil, Aniba rosaeodora(rosewood) essential oil, apricot kernel oil, Arctostaphylos uva ursiextract, Argania spinosa (argan) oil, argirilene, astaxanthin, betaglucan, Borago officinalis (borage) oil, Boswellia carterii(frankincense) essential oil, Caesalpinia spinosa (tara) gum], calciumcarbonate, Camellia oleifera (camellia) oil, Camellia sinensis, Cannabissativa (hemp) seed oil, caprylic/capric triglyceride], Carica papaya(papaya) seed oil, cellulose gum, Centella asiatica (gotu kola) extract,ceramide 1, ceramide 3, ceramide 6 II, ceramide complex, cetearylglucoside, chitin, chitosan, cholecalciferol (vitamin D3), cholesterol,Citrullus lanatus (watermelon) extract, Citrus aurantium (neroli)hydrosol, Citrus paradisi (grapefruit) essential oil, Cocos nucifera(coconut) oil, coenzyme Q10, Crithmum maritimum (sea fennel) extract,decyl polyglucoside, dipeptide diaminobutyroyl benzylamide diacetate(snake peptides), elastin, Enteromorpha compressa extract, fatty acids,gamma-oryzanol, geranylgeranone gga, gluconolactone, glucosamine, glycanbooster [tetradecyl amino-butyroylvalyl-aminobutyric ureatrifluoro-acetate, glycerin, Glycine soja (soybean) oil, glycoproteins,Glycyrrhiza glabra (licorice root) extract, green tea extract,Gynostemma pentaphyllum (gynostemma) extract, Haematococcus pulvialis,Helianthus annuus (sunflower) seed oil, homeostatine, hyaluronic acid,hydrolyzed rice bran extract, hydroquinone, lactoceramides, Lavendulaangustfolia (lavender) essential oil, lecithin, Leontopodium alpinum(edelweiss) extract, leuconostoc/radish root ferment (leucidal),linoleic acid, magnesium ascorbyl phosphate, magnesium chloride, matrixpeptides, mixed tocopherols (vitamin E), Morus alba (mulberry) rootextract, niacinamide, noni, non-nano zinc oxide, oat beta glucans,Oenothera biennis (evening primrose) oil, oleic acid, omega 6 fattyacids, omega 9 fatty acids, omega-3 fatty acids, Oryza sativa (rice)bran oil, palmitic, palmitoyl tripeptide-5, Passiflora incarnate(passion fruit) oil, pearl powder, Persea gratissima (avocado) oil,phytosphingosine, Pinus densiflora (red pine needle) oil, Plantagospecies (plantain) leaf extract, Polianthes tuberosa (tuberose)essential oil, polyaminopropyl biguanide (cosmocil CQ),polyglucose/lactylate, Populus tremuloides (aspen) bark extract,potassium sorbate, Prunus armeniaca (apricot) kernel oil, pullulan, redpond algae, red raspberry seed oil, resveratrol, retinyl palmitate(retinol), Rosa centifolia (rose) essential oil, Rosa rubignosa(rosehip) seed oil, Rosmarinus officinalis (rosemary) oleoresin, Rubusidaeus (red raspberry) seed oil, saccharomyces ferment, Salvia hispanica(chia) seed oil, Sclerocarya birrea (marula) oil, sea kelp extract,Sesamum indicum (sesame seed) oil, Simmondsia chinensis (jojoba) oil,SOD, sodium alginate, sodium benzoate, sodium hyaluronate, sodiumlauroyl lactylate, soy peptides, soy-rice peptides [oxidoreductase],squalene, sucrose cocoate, sugar mulse [cetearyl alcohol], Tamarindusindica (tamarind) seed extract, teprenone, thioctic (alpha lipoic) acid,Trachelospermum jasminoides (star jasmine) essential oil, tripeptide-29,tripeptides, ubidecarenone, undecylenoyl phenylalanine, vitamin A,vitamin C, Vitus viniferi (grapeseed) oil, watermelon seed oil, whitetea extract, xanthan gum, and xylitum black tea ferment (kombucha)extract.

Paragraph 46. A composition comprising a crustacean tissue extract.

Paragraph 47. The composition of Paragraph 46, wherein the crustacean isParalothodes camtschaticus.

Paragraph 48. The composition of Paragraph 46, wherein the tissue isselected from the group consisting of at least one of exoskeleton,muscle, viscera, and gonad.

Paragraph 49. The composition of Paragraph 46, further comprising anextract from a marine organism.

Paragraph 50. The composition of Paragraph 49, wherein the marineorganism is selected from the group consisting of abalone, alga,bivalve, sea cucumber, and cyanobacteria.

Paragraph 51. The composition of Paragraph 50, wherein the abalone isHaliotis spp.

Paragraph 52. The composition of Paragraph 51, wherein the Haliotis spp.is selected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 53. The composition of Paragraph 50, wherein the abalone is ahybrid abalone.

Paragraph 54. The composition of Paragraph 53, wherein the hybridabalone is selected from the group consisting of Haliotis rufescens xHaliotis corrugate, Haliotis rufescens x Haliotis fulgens, and Haliotisrufescens x Haliotis laevagata.

Paragraph 55. The composition of Paragraph 50, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 56. The composition of Paragraph 50, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 57. The composition of Paragraph 50, wherein the sea cucumberis selected from the group consisting of Holothuria mexicana, Holothuriacalifornicus, Holothuria scabra, Stichopus chlorontus, Stichopushorrens, Stichopus japonicus, Apostichopus japonicus, and Cucumariajaponica.

Paragraph 58. The composition of Paragraph 50, wherein the cyanobacteriais selected from the group consisting of Spirulina pacifica, Arthrospiramaxima, Arthrospira planensis, Microcystis aeruginosa, and Microcystiswesenbergii.

Paragraph 59. The composition of Paragraph 46, further comprising acosmetic product.

Paragraph 60. The composition of Paragraph 59, wherein the cosmeticproduct is selected from the group consisting of one or more of acetylhexapeptide-3 (argirilene), acrylates/C₁₀₋₃₀ alkyl acrylatecross-polymer, Actinidia deliciosa (kiwi) seed oil, algae extract,Andropogon zizanioides (vetiver) essential oil, Aniba rosaeodora(rosewood) essential oil, apricot kernel oil, Arctostaphylos uva ursiextract, Argania spinosa (argan) oil, argirilene, astaxanthin, betaglucan, Borago officinalis (borage) oil, Boswellia carterii(frankincense) essential oil, Caesalpinia spinosa (tara) gum], calciumcarbonate, Camellia oleifera (camellia) oil, Camellia sinensis, Cannabissativa (hemp) seed oil, caprylic/capric triglyceride], Carica papaya(papaya) seed oil, cellulose gum, Centella asiatica (gotu kola) extract,ceramide 1, ceramide 3, ceramide 6 II, ceramide complex, cetearylglucoside, chitin, chitosan, cholecalciferol (vitamin D3), cholesterol,Citrullus lanatus (watermelon) extract, Citrus aurantium (neroli)hydrosol, Citrus paradisi (grapefruit) essential oil, Cocos nucifera(coconut) oil, coenzyme Q10, Crithmum maritimum (sea fennel) extract,decyl polyglucoside, dipeptide diaminobutyroyl benzylamide diacetate(snake peptides), elastin, Enteromorpha compressa extract, fatty acids,gamma-oryzanol, geranylgeranone gga, gluconolactone, glucosamine, glycanbooster [tetradecyl amino-butyroylvalyl-aminobutyric ureatrifluoro-acetate, glycerin, Glycine soja (soybean) oil, glycoproteins,Glycyrrhiza glabra (licorice root) extract, green tea extract,Gynostemma pentaphyllum (gynostemma) extract, Haematococcus pulvialis,Helianthus annuus (sunflower) seed oil, homeostatine, hyaluronic acid,hydrolyzed rice bran extract, hydroquinone, lactoceramides, Lavendulaangustfolia (lavender) essential oil, lecithin, Leontopodium alpinum(edelweiss) extract, leuconostoc/radish root ferment (leucidal),linoleic acid, magnesium ascorbyl phosphate, magnesium chloride, matrixpeptides, mixed tocopherols (vitamin E), Morus alba (mulberry) rootextract, niacinamide, noni, non-nano zinc oxide, oat beta glucans,Oenothera biennis (evening primrose) oil, oleic acid, omega 6 fattyacids, omega 9 fatty acids, omega-3 fatty acids, Oryza sativa (rice)bran oil, palmitic, palmitoyl tripeptide-5, Passiflora incarnate(passion fruit) oil, pearl powder, Persea gratissima (avocado) oil,phytosphingosine, Pinus densiflora (red pine needle) oil, Plantagospecies (plantain) leaf extract, Polianthes tuberosa (tuberose)essential oil, polyaminopropyl biguanide (cosmocil CQ),polyglucose/lactylate, Populus tremuloides (aspen) bark extract,potassium sorbate, Prunus armeniaca (apricot) kernel oil, pullulan, redpond algae, red raspberry seed oil, resveratrol, retinyl palmitate(retinol), Rosa centifolia (rose) essential oil, Rosa rubignosa(rosehip) seed oil, Rosmarinus officinalis (rosemary) oleoresin, Rubusidaeus (red raspberry) seed oil, saccharomyces ferment, Salvia hispanica(chia) seed oil, Sclerocarya birrea (marula) oil, sea kelp extract,Sesamum indicum (sesame seed) oil, Simmondsia chinensis (jojoba) oil,SOD, sodium alginate, sodium benzoate, sodium hyaluronate, sodiumlauroyl lactylate, soy peptides, soy-rice peptides [oxidoreductase],squalene, sucrose cocoate, sugar mulse [cetearyl alcohol], Tamarindusindica (tamarind) seed extract, teprenone, thioctic (alpha lipoic) acid,Trachelospermum jasminoides (star jasmine) essential oil, tripeptide-29,tripeptides, ubidecarenone, undecylenoyl phenylalanine, vitamin A,vitamin C, Vitus viniferi (grapeseed) oil, watermelon seed oil, whitetea extract, xanthan gum, and xylitum black tea ferment (kombucha)extract.

Paragraph 61. A composition comprising a sea cucumber tissue extract.

Paragraph 62. The composition of Paragraph 61, wherein the sea cucumberis selected from the group consisting of Holothuria mexicana, Holothuriacalifornicus, Holothuria scabra, Stichopus chlorontus, Stichopushorrens, Stichopus japonicus, Apostichopus japonicus, and Cucumariajaponica.

Paragraph 63. The composition of Paragraph 61, wherein the tissue isselected from the group consisting of at least one of body wall, muscle,viscera, and gonad.

Paragraph 64. The composition of Paragraph 61, further comprising anextract from a marine organism.

Paragraph 65. The composition of Paragraph 64, wherein the marineorganism is selected from the group consisting of abalone alga, bivalve,crustacean, and cyanobacteria.

Paragraph 66. The composition of Paragraph 65, wherein the abalone isHaliotis spp.

Paragraph 67. The composition of Paragraph 66, wherein the Haliotis spp.is selected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 68. The composition of Paragraph 65, wherein the abalone is ahybrid abalone.

Paragraph 69. The composition of Paragraph 68, wherein the hybridabalone is selected from the group consisting of Haliotis rufescens xHaliotis corrugate, Haliotis rufescens x Haliotis fulgens, and Haliotisrufescens x Haliotis laevagata.

Paragraph 70. The composition of Paragraph 65, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 71. The composition of Paragraph 65, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 72. The composition of Paragraph 65, wherein the crustacean isParalothodes camtschaticus.

Paragraph 73. The composition of Paragraph 65, wherein the cyanobacteriais selected from the group consisting of Spirulina pacifica, Arthrospiramaxima, Arthrospira planensis, Microcystis aeruginosa, and Microcystiswesenbergii.

Paragraph 74. The composition of Paragraph 61, further comprising acosmetic product.

Paragraph 75. The composition of Paragraph 74, wherein the cosmeticproduct is selected from the group consisting of one or more of acetylhexapeptide-3 (argirilene), acrylates/C₁₀₋₃₀ alkyl acrylatecross-polymer, Actinidia deliciosa (kiwi) seed oil, algae extract,Andropogon zizanioides (vetiver) essential oil, Aniba rosaeodora(rosewood) essential oil, apricot kernel oil, Arctostaphylos uva ursiextract, Argania spinosa (argan) oil, argirilene, astaxanthin, betaglucan, Borago officinalis (borage) oil, Boswellia carterii(frankincense) essential oil, Caesalpinia spinosa (tara) gum], calciumcarbonate, Camellia oleifera (camellia) oil, Camellia sinensis, Cannabissativa (hemp) seed oil, caprylic/capric triglyceride], Carica papaya(papaya) seed oil, cellulose gum, Centella asiatica (gotu kola) extract,ceramide 1, ceramide 3, ceramide 6 II, ceramide complex, cetearylglucoside, chitin, chitosan, cholecalciferol (vitamin D3), cholesterol,Citrullus lanatus (watermelon) extract, Citrus aurantium (neroli)hydrosol, Citrus paradisi (grapefruit) essential oil, Cocos nucifera(coconut) oil, coenzyme Q10, Crithmum maritimum (sea fennel) extract,decyl polyglucoside, dipeptide diaminobutyroyl benzylamide diacetate(snake peptides), elastin, Enteromorpha compressa extract, fatty acids,gamma-oryzanol, geranylgeranone gga, gluconolactone, glucosamine, glycanbooster [tetradecyl amino-butyroylvalyl-aminobutyric ureatrifluoro-acetate, glycerin, Glycine soja (soybean) oil, glycoproteins,Glycyrrhiza glabra (licorice root) extract, green tea extract,Gynostemma pentaphyllum (gynostemma) extract, Haematococcus pulvialis,Helianthus annuus (sunflower) seed oil, homeostatine, hyaluronic acid,hydrolyzed rice bran extract, hydroquinone, lactoceramides, Lavendulaangustfolia (lavender) essential oil, lecithin, Leontopodium alpinum(edelweiss) extract, leuconostoc/radish root ferment (leucidal),linoleic acid, magnesium ascorbyl phosphate, magnesium chloride, matrixpeptides, mixed tocopherols (vitamin E), Morus alba (mulberry) rootextract, niacinamide, noni, non-nano zinc oxide, oat beta glucans,Oenothera biennis (evening primrose) oil, oleic acid, omega 6 fattyacids, omega 9 fatty acids, omega-3 fatty acids, Oryza sativa (rice)bran oil, palmitic, palmitoyl tripeptide-5, Passiflora incarnate(passion fruit) oil, pearl powder, Persea gratissima (avocado) oil,phytosphingosine, Pinus densiflora (red pine needle) oil, Plantagospecies (plantain) leaf extract, Polianthes tuberosa (tuberose)essential oil, polyaminopropyl biguanide (cosmocil CQ),polyglucose/lactylate, Populus tremuloides (aspen) bark extract,potassium sorbate, Prunus armeniaca (apricot) kernel oil, pullulan, redpond algae, red raspberry seed oil, resveratrol, retinyl palmitate(retinol), Rosa centifolia (rose) essential oil, Rosa rubignosa(rosehip) seed oil, Rosmarinus officinalis (rosemary) oleoresin, Rubusidaeus (red raspberry) seed oil, saccharomyces ferment, Salvia hispanica(chia) seed oil, Sclerocarya birrea (marula) oil, sea kelp extract,Sesamum indicum (sesame seed) oil, Simmondsia chinensis (jojoba) oil,SOD, sodium alginate, sodium benzoate, sodium hyaluronate, sodiumlauroyl lactylate, soy peptides, soy-rice peptides [oxidoreductase],squalene, sucrose cocoate, sugar mulse [cetearyl alcohol], Tamarindusindica (tamarind) seed extract, teprenone, thioctic (alpha lipoic) acid,Trachelospermum jasminoides (star jasmine) essential oil, tripeptide-29,tripeptides, ubidecarenone, undecylenoyl phenylalanine, vitamin A,vitamin C, Vitus viniferi (grapeseed) oil, watermelon seed oil, whitetea extract, xanthan gum, and xylitum black tea ferment (kombucha)extract.

Paragraph 76. A composition comprising an cyanobacteria extract.

Paragraph 77. The composition of Paragraph 76, wherein the cyanobacteriais selected from the group consisting of Spirulina pacifica, Arthrospiramaxima, Arthrospira planensis, Microcystis aeruginosa, and Microcystiswesenbergii.

Paragraph 78. The composition of Paragraph 76, further comprising anextract from a marine organism.

Paragraph 79. The composition of Paragraph 78, wherein the marineorganism is selected from the group consisting of alga, bivalve,crustacean, sea cucumber, and cyanobacteria.

Paragraph 80. The composition of Paragraph 79, wherein the abalone isHaliotis spp.

Paragraph 81. The composition of Paragraph 80, wherein the Haliotis spp.is selected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 82. The composition of Paragraph 79, wherein the abalone is ahybrid abalone.

Paragraph 83. The composition of Paragraph 82, wherein the hybridabalone is selected from the group consisting of Haliotis rufescens xHaliotis corrugate, Haliotis rufescens x Haliotis fulgens, and Haliotisrufescens x Haliotis laevagata.

Paragraph 84. The composition of Paragraph 79, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 85. The composition of Paragraph 79 wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 86. The composition of Paragraph 79 wherein the crustacean isParalothodes camtschaticus.

Paragraph 87. The composition of Paragraph 79 wherein the sea cucumberis selected from the group consisting of Holothuria mexicana, Holothuriacalifornicus, Holothuria scabra, Stichopus chlorontus, Stichopushorrens, Stichopus japonicus, Apostichopus japonicus, and Cucumariajaponica.

Paragraph 88. The composition of Paragraph 76, further comprising acosmetic product.

Paragraph 89. The composition of Paragraph 88 wherein the cosmeticproduct is selected from the group consisting of one or more of acetylhexapeptide-3 (argirilene), acrylates/C₁₀₋₃₀ alkyl acrylatecross-polymer, Actinidia deliciosa (kiwi) seed oil, algae extract,Andropogon zizanioides (vetiver) essential oil, Aniba rosaeodora(rosewood) essential oil, apricot kernel oil, Arctostaphylos uva ursiextract, Argania spinosa (argan) oil, argirilene, astaxanthin, betaglucan, Borago officinalis (borage) oil, Boswellia carterii(frankincense) essential oil, Caesalpinia spinosa (tara) gum], calciumcarbonate, Camellia oleifera (camellia) oil, Camellia sinensis, Cannabissativa (hemp) seed oil, caprylic/capric triglyceride], Carica papaya(papaya) seed oil, cellulose gum, Centella asiatica (gotu kola) extract,ceramide 1, ceramide 3, ceramide 6 II, ceramide complex, cetearylglucoside, chitin, chitosan, cholecalciferol (vitamin D3), cholesterol,Citrullus lanatus (watermelon) extract, Citrus aurantium (neroli)hydrosol, Citrus paradisi (grapefruit) essential oil, Cocos nucifera(coconut) oil, coenzyme Q10, Crithmum maritimum (sea fennel) extract,decyl polyglucoside, dipeptide diaminobutyroyl benzylamide diacetate(snake peptides), elastin, Enteromorpha compressa extract, fatty acids,gamma-oryzanol, geranylgeranone gga, gluconolactone, glucosamine, glycanbooster [tetradecyl amino-butyroylvalyl-aminobutyric ureatrifluoro-acetate, glycerin, Glycine soja (soybean) oil, glycoproteins,Glycyrrhiza glabra (licorice root) extract, green tea extract,Gynostemma pentaphyllum (gynostemma) extract, Haematococcus pulvialis,Helianthus annuus (sunflower) seed oil, homeostatine, hyaluronic acid,hydrolyzed rice bran extract, hydroquinone, lactoceramides, Lavendulaangustfolia (lavender) essential oil, lecithin, Leontopodium alpinum(edelweiss) extract, leuconostoc/radish root ferment (leucidal),linoleic acid, magnesium ascorbyl phosphate, magnesium chloride, matrixpeptides, mixed tocopherols (vitamin E), Morus alba (mulberry) rootextract, niacinamide, noni, non-nano zinc oxide, oat beta glucans,Oenothera biennis (evening primrose) oil, oleic acid, omega 6 fattyacids, omega 9 fatty acids, omega-3 fatty acids, Oryza sativa (rice)bran oil, palmitic, palmitoyl tripeptide-5, Passiflora incarnate(passion fruit) oil, pearl powder, Persea gratissima (avocado) oil,phytosphingosine, Pinus densiflora (red pine needle) oil, Plantagospecies (plantain) leaf extract, Polianthes tuberosa (tuberose)essential oil, polyaminopropyl biguanide (cosmocil CQ),polyglucose/lactylate, Populus tremuloides (aspen) bark extract,potassium sorbate, Prunus armeniaca (apricot) kernel oil, pullulan, redpond algae, red raspberry seed oil, resveratrol, retinyl palmitate(retinol), Rosa centifolia (rose) essential oil, Rosa rubignosa(rosehip) seed oil, Rosmarinus officinalis (rosemary) oleoresin, Rubusidaeus (red raspberry) seed oil, saccharomyces ferment, Salvia hispanica(chia) seed oil, Sclerocarya birrea (marula) oil, sea kelp extract,Sesamum indicum (sesame seed) oil, Simmondsia chinensis (jojoba) oil,SOD, sodium alginate, sodium benzoate, sodium hyaluronate, sodiumlauroyl lactylate, soy peptides, soy-rice peptides [oxidoreductase],squalene, sucrose cocoate, sugar mulse [cetearyl alcohol], Tamarindusindica (tamarind) seed extract, teprenone, thioctic (alpha lipoic) acid,Trachelospermum jasminoides (star jasmine) essential oil, tripeptide-29,tripeptides, ubidecarenone, undecylenoyl phenylalanine, vitamin A,vitamin C, Vitus viniferi (grapeseed) oil, watermelon seed oil, whitetea extract, xanthan gum, and xylitum black tea ferment (kombucha)extract.

Paragraph 90. A method of producing an abalone tissue extract,comprising the steps of:

a) removing a tissue from an abalone,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and.

e) collecting the solvent fraction to obtain the abalone tissue extract.

Paragraph 91. The method of Paragraph 90, wherein the abalone isHaliotis spp.

Paragraph 92. The method of Paragraph 91, wherein the Haliotis spp. isselected from the group consisting of Haliotis fulgens, Haliotisrufescens, Haliotis corrugata, Haliotis kamtschatkana, and Haliotiswalallensis.

Paragraph 93. The method of Paragraph 90, wherein the abalone is ahybrid abalone.

Paragraph 94. The method of Paragraph 93, wherein the hybrid abalone isselected from the group consisting of Haliotis rufescens x Haliotiscorrugate, Haliotis rufescens x Haliotis fulgens, and Haliotis rufescensx Haliotis laevagata.

Paragraph 95. The method of Paragraph 90, wherein the tissue is selectedfrom the group consisting of at least one of muscle, viscera, conicalappendage, digestive gland, gonad, testes and ovary.

Paragraph 96. The method of Paragraph 90, wherein the solvent isselected from the group consisting of at least one of a polar solventand a non-polar solvent.

Paragraph 97. The method of Paragraph 90, wherein the polar solvent isselected from the group consisting of at least one of dimethyl sulfoxide(DMSO), isopropyl alcohol, ethanol, methanol, acetic acid and water.

Paragraph 99. The method of Paragraph 90, wherein the non-polar solventis selected from the group consisting of at least one of hexane,chloroform and ether.

Paragraph 99. The method of Paragraph 90, wherein the method ofseparating the solvent fraction from the sediment fraction is selectedfrom the group consisting of by gravity, centrifugation, filtration,column chromatography, and HPLC.

Paragraph 100. The method of Paragraph 90, wherein the method ofbreaking up the cells in the tissue is selected from the groupconsisting of a blender, homogenizer, grinder, and mortar and pestle.

Paragraph 101. The method of Paragraph 90, further comprising step f)freeze drying the abalone tissue extract.

Paragraph 102. The method of Paragraph 90, further comprising step f)lyophilizing the abalone tissue extract.

Paragraph 103. The method of Paragraph 90, wherein between step a) andstep b) further comprising step 1) freezing the tissue.

Paragraph 104. The method of Paragraph 90, wherein between step a) andstep b) further comprising step 1) drying the tissue.

Paragraph 105. The method of Paragraph 104, further comprising step 2)separating collagen from the dried tissue and discarding the collagen.

Paragraph 106. A method of producing an alga tissue extract, comprisingthe steps of:

a) removing a tissue from an alga,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and.

e) collecting the solvent fraction to obtain the alga tissue extract.

Paragraph 107. The composition of Paragraph 106, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 108. The composition of Paragraph 106, wherein the tissue isselected from the group consisting of at least one of frond and wholebody.

Paragraph 109. The method of Paragraph 106, wherein the solvent isselected from the group consisting of at least one of a polar solventand a non-polar solvent.

Paragraph 110. The method of Paragraph 106, wherein the polar solvent isselected from the group consisting of at least one of dimethyl sulfoxide(DMSO), isopropyl alcohol, ethanol, methanol, acetic acid and water.

Paragraph 112. The method of Paragraph 106, wherein the non-polarsolvent is selected from the group consisting of at least one of hexane,chloroform and ether.

Paragraph 113. The method of Paragraph 106, wherein the method ofseparating the solvent fraction from the sediment fraction is selectedfrom the group consisting of by gravity, centrifugation, filtration,column chromatography, and HPLC.

Paragraph 114. The method of Paragraph 106, wherein the method ofbreaking up the cells in the tissue is selected from the groupconsisting of a blender, homogenizer, grinder, and mortar and pestle.

Paragraph 115. The method of Paragraph 106, further comprising step f)freeze drying the alga tissue extract.

Paragraph 116. The method of Paragraph 106, further comprising step f)lyophilizing the alga tissue extract.

Paragraph 117. The method of Paragraph 106, wherein between step a) andstep b) further comprising step 1) freezing the tissue.

Paragraph 118. The method of Paragraph 106, wherein between step a) andstep b) further comprising step 1) drying the tissue.

Paragraph 119. A method of producing a bivalve tissue extract,comprising the steps of:

a) removing a tissue from a bivalve,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and

e) collecting the solvent fraction to obtain the bivalve tissue extract.

Paragraph 120. The composition of Paragraph 119, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 121. The composition of Paragraph 119, wherein the tissue isselected from the group consisting of at least one of adductor muscle,viscera, and gonad.

Paragraph 122. The method of Paragraph 119, wherein the solvent isselected from the group consisting of at least one of a polar solventand a non-polar solvent.

Paragraph 123. The method of Paragraph 119, wherein the polar solvent isselected from the group consisting of at least one of dimethyl sulfoxide(DMSO), isopropyl alcohol, ethanol, methanol, acetic acid and water.

Paragraph 124. The method of Paragraph 119, wherein the non-polarsolvent is selected from the group consisting of at least one of hexane,chloroform and ether.

Paragraph 125. The method of Paragraph 119, wherein the method ofseparating the solvent fraction from the sediment fraction is selectedfrom the group consisting of by gravity, centrifugation, filtration,column chromatography, and HPLC.

Paragraph 126. The method of Paragraph 119, wherein the method ofbreaking up the cells in the tissue is selected from the groupconsisting of a blender, homogenizer, grinder, and mortar and pestle.

Paragraph 127. The method of Paragraph 119, further comprising step f)freeze drying the bivalve tissue extract.

Paragraph 128. The method of Paragraph 119, further comprising step f)lyophilizing the bivalve tissue extract.

Paragraph 129. The method of Paragraph 119, wherein between step a) andstep b) further comprising step 1) freezing the tissue.

Paragraph 130. The method of Paragraph 119, wherein between step a) andstep b) further comprising step 1) drying the tissue.

Paragraph 131. A method of producing a crustacean tissue extract,comprising the steps of:

a) removing a tissue from a crustacean,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and

e) collecting the solvent fraction to obtain the crustacean tissueextract.

Paragraph 132. The composition of Paragraph 131, wherein the crustaceanis Paralothodes camtschaticus.

Paragraph 133. The composition of Paragraph 131, wherein the tissue isselected from the group consisting of at least one of exoskeleton,muscle, viscera, and gonad.

Paragraph 134. The method of Paragraph 131, wherein the solvent isselected from the group consisting of at least one of a polar solventand a non-polar solvent.

Paragraph 135. The method of Paragraph 131, wherein the polar solvent isselected from the group consisting of at least one of dimethyl sulfoxide(DMSO), isopropyl alcohol, ethanol, methanol, acetic acid and water.

Paragraph 136. The method of Paragraph 131, wherein the non-polarsolvent is selected from the group consisting of at least one of hexane,chloroform and ether.

Paragraph 137. The method of Paragraph 131, wherein the method ofseparating the solvent fraction from the sediment fraction is selectedfrom the group consisting of by gravity, centrifugation, filtration,column chromatography, and HPLC.

Paragraph 138. The method of Paragraph 131, wherein the method ofbreaking up the cells in the tissue is selected from the groupconsisting of a blender, homogenizer, grinder, and mortar and pestle.

Paragraph 139. The method of Paragraph 131, further comprising step f)freeze drying the crustacean tissue extract.

Paragraph 140. The method of Paragraph 131, further comprising step f)lyophilizing the crustacean tissue extract.

Paragraph 141. The method of Paragraph 131, wherein between step a) andstep b) further comprising step 1) freezing the tissue.

Paragraph 142. The method of Paragraph 131, wherein between step a) andstep b) further comprising step 1) drying the tissue.

Paragraph 143. A method of producing a sea cucumber tissue extract,comprising the steps of:

a) removing a tissue from a sea cucumber,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and

e) collecting the solvent fraction to obtain the sea cucumber tissueextract.

Paragraph 144. The composition of Paragraph 143, wherein the seacucumber is selected from the group consisting of Holothuria mexicana,Holothuria californicus, Holothuria scabra, Stichopus chlorontus,Stichopus horrens, Stichopus japonicus, Apostichopus japonicus, andCucumaria japonica.

Paragraph 145. The composition of Paragraph 143, wherein the tissue isselected from the group consisting of at least one of body wall, muscle,viscera, and gonad.

Paragraph 146. The method of Paragraph 143, wherein the solvent isselected from the group consisting of at least one of a polar solventand a non-polar solvent.

Paragraph 147. The method of Paragraph 143, wherein the polar solvent isselected from the group consisting of at least one of dimethyl sulfoxide(DMSO), isopropyl alcohol, ethanol, methanol, acetic acid and water.

Paragraph 148. The method of Paragraph 143, wherein the non-polarsolvent is selected from the group consisting of at least one of hexane,chloroform and ether.

Paragraph 149. The method of Paragraph 143, wherein the method ofseparating the solvent fraction from the sediment fraction is selectedfrom the group consisting of by gravity, centrifugation, filtration,column chromatography, and HPLC.

Paragraph 150. The method of Paragraph 143, wherein the method ofbreaking up the cells in the tissue is selected from the groupconsisting of a blender, homogenizer, grinder, and mortar and pestle.

Paragraph 151. The method of Paragraph 143, further comprising step f)freeze drying the sea cucumber tissue extract.

Paragraph 152. The method of Paragraph 143, further comprising step f)lyophilizing the sea cucumber tissue extract.

Paragraph 153. The method of Paragraph 143, wherein between step a) andstep b) further comprising step 1) freezing the tissue.

Paragraph 154. The method of Paragraph 143, wherein between step a) andstep b) further comprising step 1) drying the tissue.

Paragraph 155. A method of producing a cyanobacteria extract, comprisingthe steps of:

a) breaking up the cells,

b) adding a solvent,

c) separating the solvent fraction from a sediment fraction, and

d) collecting the solvent fraction to obtain the cyanobacteria extract.

Paragraph 156. The composition of Paragraph 155, wherein thecyanobacteria is selected from the group consisting of Spirulinapacifica, Arthrospira maxima, Arthrospira planensis, Microcystisaeruginosa, and Microcystis wesenbergii.

Paragraph 157. The method of Paragraph 155, wherein the solvent isselected from the group consisting of at least one of a polar solventand a non-polar solvent.

Paragraph 158. The method of Paragraph 155, wherein the polar solvent isselected from the group consisting of at least one of dimethyl sulfoxide(DMSO), isopropyl alcohol, ethanol, methanol, acetic acid and water.

Paragraph 159. The method of Paragraph 155, wherein the non-polarsolvent is selected from the group consisting of at least one of hexane,chloroform and ether.

Paragraph 160. The method of Paragraph 155, wherein the method ofseparating the solvent fraction from the sediment fraction is selectedfrom the group consisting of by gravity, centrifugation, filtration,column chromatography, and HPLC.

Paragraph 161. The method of Paragraph 155, wherein the method ofbreaking up the cells in the tissue is selected from the groupconsisting of a blender, homogenizer, grinder, and mortar and pestle.

Paragraph 162. The method of Paragraph 155, further comprising step e)freeze drying the cyanobacteria extract.

Paragraph 163. The method of Paragraph 155, further comprising step e)lyophilizing the cyanobacteria extract.

Paragraph 164. The method of Paragraph 155, wherein before step a)further comprising step 1) freezing the cyanobacteria.

Paragraph 165. The method of Paragraph 155, wherein before step a)further comprising step 1) drying the cyanobacteria.

Paragraph 166. A method of treating skin, comprising the steps of:

a) topically applying a composition comprising an abalone tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 167. The method of Paragraph 166, wherein the skin ailment isselected from the group consisting of fine lines, wrinkles, sagging,large pores, lentigines, keratoses, rosacea, dry skin, irritated skinand sensitive skin.

Paragraph 168. The method of Paragraph 166, wherein the skin ailment isdue to a cause selected from the group consisting of sun light,ultraviolet light, wind, heat, humidity, soaps, age and health.

Paragraph 169. A method of treating skin, comprising the steps of:

a) topically applying a composition comprising an alga tissue extract tothe surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 170. The method of Paragraph 169, wherein the skin ailment isselected from the group consisting of fine lines, wrinkles, sagging,large pores, lentigines, keratoses, rosacea, dry skin, irritated skinand sensitive skin.

Paragraph 171. The method of Paragraph 169, wherein the skin ailment isdue to a cause selected from the group consisting of sun light,ultraviolet light, wind, heat, humidity, soaps, age and health.

Paragraph 172. A method of treating skin, comprising the steps of:

a) topically applying a composition comprising a bivalve tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 173. The method of Paragraph 172, wherein the skin ailment isselected from the group consisting of fine lines, wrinkles, sagging,large pores, lentigines, keratoses, rosacea, dry skin, irritated skinand sensitive skin.

Paragraph 174. The method of Paragraph 172, wherein the skin ailment isdue to a cause selected from the group consisting of sun light,ultraviolet light, wind, heat, humidity, soaps, age and health.

Paragraph 175. A method of treating skin, comprising the steps of:

a) topically applying a composition comprising a crustacean tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 176. The method of Paragraph 175, wherein the skin ailment isselected from the group consisting of fine lines, wrinkles, sagging,large pores, lentigines, keratoses, rosacea, dry skin, irritated skinand sensitive skin.

Paragraph 177. The method of Paragraph 175, wherein the skin ailment isdue to a cause selected from the group consisting of sun light,ultraviolet light, wind, heat, humidity, soaps, age and health.

Paragraph 178. A method of treating skin, comprising the steps of:

a) topically applying a composition comprising a sea cucumber tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 179. The method of Paragraph 178, wherein the skin ailment isselected from the group consisting of fine lines, wrinkles, sagging,large pores, lentigines, keratoses, rosacea, dry skin, irritated skinand sensitive skin.

Paragraph 180. The method of Paragraph 178, wherein the skin ailment isdue to a cause selected from the group consisting of sun light,ultraviolet light, wind, heat, humidity, soaps, age and health.

Paragraph 181. A method of treating skin, comprising the steps of:

a) topically applying a composition comprising a cyanobacteria extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 182. The method of Paragraph 181, wherein the skin ailment isselected from the group consisting of fine lines, wrinkles, sagging,large pores, lentigines, keratoses, rosacea, dry skin, irritated skinand sensitive skin.

Paragraph 183. The method of Paragraph 181, wherein the skin ailment isdue to a cause selected from the group consisting of sun light,ultraviolet light, wind, heat, humidity, soaps, age and health.

Paragraph 184. A method of increasing the production of Hyaluronic acid,comprising the steps of:

a) topically applying a composition comprising an abalone tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 185. A method of increasing the production of elastin,comprising the steps of:

a) topically applying a composition comprising an abalone tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 186. A method of increasing the production of collagen,comprising the steps of:

a) topically applying a composition comprising an abalone tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 187. A method of increasing the production of Hyaluronic acid,comprising the steps of:

a) topically applying a composition comprising an alga tissue extract tothe surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 188. A method of increasing the production of elastin,comprising the steps of:

a) topically applying a composition comprising an alga tissue extract tothe surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 189. A method of increasing the production of collagen,comprising the steps of:

a) topically applying a composition comprising an alga tissue extract tothe surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 190. A method of increasing the production of Hyaluronic acid,comprising the steps of:

a) topically applying a composition comprising a bivalve tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 191. A method of increasing the production of elastin,comprising the steps of:

a) topically applying a composition comprising a bivalve tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 192. A method of increasing the production of collagen,comprising the steps of:

a) topically applying a composition comprising a bivalve tissue extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 193. A method of increasing the production of Hyaluronic acid,comprising the steps of:

a) topically applying a composition comprising a crustacean tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 194. A method of increasing the production of elastin,comprising the steps of:

a) topically applying a composition comprising a crustacean tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 195. A method of increasing the production of collagen,comprising the steps of:

a) topically applying a composition comprising a crustacean tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 196. A method of increasing the production of Hyaluronic acid,comprising the steps of:

a) topically applying a composition comprising a sea cucumber tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 197. A method of increasing the production of elastin,comprising the steps of:

a) topically applying a composition comprising a sea cucumber tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 198. A method of increasing the production of collagen,comprising the steps of:

a) topically applying a composition comprising a sea cucumber tissueextract to the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 199. A method of increasing the production of Hyaluronic acid,comprising the steps of:

a) topically applying a composition comprising a cyanobacteria extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 200. A method of increasing the production of elastin,comprising the steps of:

a) topically applying a composition comprising a cyanobacteria extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 201. A method of increasing the production of collagen,comprising the steps of:

a) topically applying a composition comprising a cyanobacteria extractto the surface of the skin with a skin ailment, and

b) applying the composition for at least 7 days.

Paragraph 202. A product of the process, comprising the steps of:

a) removing a tissue from an abalone,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and.

e) collecting the solvent fraction to obtain the abalone tissue extract.

Paragraph 203. The product of the process of Paragraph 202, wherein theabalone is Haliotis spp.

Paragraph 204. The product of the process of Paragraph 203, wherein theHaliotis spp. is selected from the group consisting of Haliotis fulgens,Haliotis rufescens, Haliotis corrugata, Haliotis kamtschatkana, andHaliotis walallensis.

Paragraph 205. The product of the process of Paragraph 202, wherein theabalone is a hybrid abalone.

Paragraph 206. The product of the process of Paragraph 205, wherein thehybrid abalone is selected from the group consisting of Haliotisrufescens x Haliotis corrugate, Haliotis rufescens x Haliotis fulgens,and Haliotis rufescens x Haliotis laevagata.

Paragraph 207. The product of the process of Paragraph 202, wherein thetissue is selected from the group consisting of at least one of muscle,viscera, conical appendage, digestive gland, gonad, testes and ovary.

Paragraph 208. The product of the process of Paragraph 202, wherein thesolvent is selected from the group consisting of at least one of a polarsolvent and a non-polar solvent.

Paragraph 209. The product of the process of Paragraph 202, wherein thepolar solvent is selected from the group consisting of at least one ofdimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, aceticacid and water.

Paragraph 210. The product of the process of Paragraph 202, wherein thenon-polar solvent is selected from the group consisting of at least oneof hexane, chloroform and ether.

Paragraph 211. The product of the process of Paragraph 202, wherein Theproduct of the process of separating the solvent fraction from thesediment fraction is selected from the group consisting of by gravity,centrifugation, filtration, column chromatography, and HPLC.

Paragraph 212. The product of the process of Paragraph 202, wherein Theproduct of the process of breaking up the cells in the tissue isselected from the group consisting of a blender, homogenizer, grinder,and mortar and pestle.

Paragraph 213. The product of the process of Paragraph 202, furthercomprising step f) freeze drying the abalone tissue extract.

Paragraph 214. The product of the process of Paragraph 202, furthercomprising step f) lyophilizing the abalone tissue extract.

Paragraph 215. The product of the process of Paragraph 202, whereinbetween step a) and step b) further comprising step 1) freezing thetissue.

Paragraph 216. The product of the process of Paragraph 202, whereinbetween step a) and step b) further comprising step 1) drying thetissue.

Paragraph 217. The product of the process of Paragraph 104, furthercomprising step 2) separating collagen from the dried tissue anddiscarding the collagen.

Paragraph 218. A product of the process, comprising the steps of:

a) removing a tissue from an alga,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and.

e) collecting the solvent fraction to obtain the alga tissue extract.

Paragraph 219. The composition of Paragraph 218, wherein the alga isselected from the group consisting of Macrocystis integrifolia,Macrocystis pyrifera, Fucus vesiculosis, Ascophyllum nodosum, Spirulinapacifica, Sargassum muticum, Chlorella pyrenoidosa, and Chlorellavariabilis.

Paragraph 220. The composition of Paragraph 218, wherein the tissue isselected from the group consisting of at least one of frond and wholebody.

Paragraph 221. The product of the process of Paragraph 218, wherein thesolvent is selected from the group consisting of at least one of a polarsolvent and a non-polar solvent.

Paragraph 222. The product of the process of Paragraph 218, wherein thepolar solvent is selected from the group consisting of at least one ofdimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, aceticacid and water.

Paragraph 223. The product of the process of Paragraph 218, wherein thenon-polar solvent is selected from the group consisting of at least oneof hexane, chloroform and ether.

Paragraph 224. The product of the process of Paragraph 218, wherein Theproduct of the process of separating the solvent fraction from thesediment fraction is selected from the group consisting of by gravity,centrifugation, filtration, column chromatography, and HPLC.

Paragraph 225. The product of the process of Paragraph 218, wherein Theproduct of the process of breaking up the cells in the tissue isselected from the group consisting of a blender, homogenizer, grinder,and mortar and pestle.

Paragraph 226. The product of the process of Paragraph 218, furthercomprising step f) freeze drying the alga tissue extract.

Paragraph 227. The product of the process of Paragraph 218, furthercomprising step f) lyophilizing the alga tissue extract.

Paragraph 228. The product of the process of Paragraph 218, whereinbetween step a) and step b) further comprising step 1) freezing thetissue.

Paragraph 229. The product of the process of Paragraph 218, whereinbetween step a) and step b) further comprising step 1) drying thetissue.

Paragraph 230. A product of the process, comprising the steps of:

a) removing a tissue from a bivalve,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and

e) collecting the solvent fraction to obtain the bivalve tissue extract.

Paragraph 231. The composition of Paragraph 230, wherein the bivalve isselected from the group consisting of Chlamys rubida, Chlamys hastate,Crassotrea gigas, Crassotrea corteziensis, and Crassotrea columbiensis.

Paragraph 232. The composition of Paragraph 230, wherein the tissue isselected from the group consisting of at least one of adductor muscle,viscera, and gonad.

Paragraph 233. The product of the process of Paragraph 230, wherein thesolvent is selected from the group consisting of at least one of a polarsolvent and a non-polar solvent.

Paragraph 234. The product of the process of Paragraph 230, wherein thepolar solvent is selected from the group consisting of at least one ofdimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, aceticacid and water.

Paragraph 235. The product of the process of Paragraph 230, wherein thenon-polar solvent is selected from the group consisting of at least oneof hexane, chloroform and ether.

Paragraph 236. The product of the process of Paragraph 230, wherein Theproduct of the process of separating the solvent fraction from thesediment fraction is selected from the group consisting of by gravity,centrifugation, filtration, column chromatography, and HPLC.

Paragraph 237. The product of the process of Paragraph 230, wherein Theproduct of the process of breaking up the cells in the tissue isselected from the group consisting of a blender, homogenizer, grinder,and mortar and pestle.

Paragraph 238. The product of the process of Paragraph 230, furthercomprising step f) freeze drying the bivalve tissue extract.

Paragraph 239. The product of the process of Paragraph 230, furthercomprising step f) lyophilizing the bivalve tissue extract.

Paragraph 240. The product of the process of Paragraph 230, whereinbetween step a) and step b) further comprising step 1) freezing thetissue.

Paragraph 241. The product of the process of Paragraph 230, whereinbetween step a) and step b) further comprising step 1) drying thetissue.

Paragraph 242. A product of the process, comprising the steps of:

a) removing a tissue from a crustacean,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and

e) collecting the solvent fraction to obtain the crustacean tissueextract.

Paragraph 243. The composition of Paragraph 242, wherein the crustaceanis Paralothodes camtschaticus.

Paragraph 244. The composition of Paragraph 242, wherein the tissue isselected from the group consisting of at least one of exoskeleton,muscle, viscera, and gonad.

Paragraph 245. The product of the process of Paragraph 242, wherein thesolvent is selected from the group consisting of at least one of a polarsolvent and a non-polar solvent.

Paragraph 246. The product of the process of Paragraph 242, wherein thepolar solvent is selected from the group consisting of at least one ofdimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, aceticacid and water.

Paragraph 247. The product of the process of Paragraph 242, wherein thenon-polar solvent is selected from the group consisting of at least oneof hexane, chloroform and ether.

Paragraph 248. The product of the process of Paragraph 242, wherein Theproduct of the process of separating the solvent fraction from thesediment fraction is selected from the group consisting of by gravity,centrifugation, filtration, column chromatography, and HPLC.

Paragraph 249. The product of the process of Paragraph 242, wherein Theproduct of the process of breaking up the cells in the tissue isselected from the group consisting of a blender, homogenizer, grinder,and mortar and pestle.

Paragraph 250. The product of the process of Paragraph 242, furthercomprising step f) freeze drying the crustacean tissue extract.

Paragraph 251. The product of the process of Paragraph 242, furthercomprising step f) lyophilizing the crustacean tissue extract.

Paragraph 252. The product of the process of Paragraph 242, whereinbetween step a) and step b) further comprising step 1) freezing thetissue.

Paragraph 253. The product of the process of Paragraph 242, whereinbetween step a) and step b) further comprising step 1) drying thetissue.

Paragraph 254. A product of the process, comprising the steps of:

a) removing a tissue from a sea cucumber,

b) breaking up the cells in the tissue,

c) adding a solvent,

d) separating the solvent fraction from a sediment fraction, and

e) collecting the solvent fraction to obtain the sea cucumber tissueextract.

Paragraph 255. The composition of Paragraph 254, wherein the seacucumber is selected from the group consisting of Holothuria mexicana,Holothuria californicus, Holothuria scabra, Stichopus chlorontus,Stichopus horrens, Stichopus japonicus, Apostichopus japonicus, andCucumaria japonica.

Paragraph 256. The composition of Paragraph 254, wherein the tissue isselected from the group consisting of at least one of body wall, muscle,viscera, and gonad.

Paragraph 257. The product of the process of Paragraph 254, wherein thesolvent is selected from the group consisting of at least one of a polarsolvent and a non-polar solvent.

Paragraph 258. The product of the process of Paragraph 254, wherein thepolar solvent is selected from the group consisting of at least one ofdimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, aceticacid and water.

Paragraph 259. The product of the process of Paragraph 254, wherein thenon-polar solvent is selected from the group consisting of at least oneof hexane, chloroform and ether.

Paragraph 260. The product of the process of Paragraph 254, wherein Theproduct of the process of separating the solvent fraction from thesediment fraction is selected from the group consisting of by gravity,centrifugation, filtration, column chromatography, and HPLC.

Paragraph 261. The product of the process of Paragraph 254, wherein Theproduct of the process of breaking up the cells in the tissue isselected from the group consisting of a blender, homogenizer, grinder,and mortar and pestle.

Paragraph 262. The product of the process of Paragraph 254, furthercomprising step f) freeze drying the sea cucumber tissue extract.

Paragraph 263. The product of the process of Paragraph 254, furthercomprising step f) lyophilizing the sea cucumber tissue extract.

Paragraph 264. The product of the process of Paragraph 254, whereinbetween step a) and step b) further comprising step 1) freezing thetissue.

Paragraph 265. The product of the process of Paragraph 254, whereinbetween step a) and step b) further comprising step 1) drying thetissue.

Paragraph 266. A product of the process, comprising the steps of:

a) breaking up the cells,

b) adding a solvent,

c) separating the solvent fraction from a sediment fraction, and

d) collecting the solvent fraction to obtain the cyanobacteria extract.

Paragraph 267. The composition of Paragraph 266, wherein thecyanobacteria is selected from the group consisting of Spirulinapacifica, Arthrospira maxima, Arthrospira planensis, Microcystisaeruginosa, and Microcystis wesenbergii.

Paragraph 268. The product of the process of Paragraph 266, wherein thesolvent is selected from the group consisting of at least one of a polarsolvent and a non-polar solvent.

Paragraph 269. The product of the process of Paragraph 266, wherein thepolar solvent is selected from the group consisting of at least one ofdimethyl sulfoxide (DMSO), isopropyl alcohol, ethanol, methanol, aceticacid and water.

Paragraph 270. The product of the process of Paragraph 266, wherein thenon-polar solvent is selected from the group consisting of at least oneof hexane, chloroform and ether.

Paragraph 271. The product of the process of Paragraph 266, wherein Theproduct of the process of separating the solvent fraction from thesediment fraction is selected from the group consisting of by gravity,centrifugation, filtration, column chromatography, and HPLC.

Paragraph 272. The product of the process of Paragraph 266, wherein Theproduct of the process of breaking up the cells in the tissue isselected from the group consisting of a blender, homogenizer, grinder,and mortar and pestle.

Paragraph 273. The product of the process of Paragraph 266, furthercomprising step e) freeze drying the cyanobacteria extract.

Paragraph 274. The product of the process of Paragraph 266, furthercomprising step e) lyophilizing the cyanobacteria extract.

Paragraph 275. The product of the process of Paragraph 266, whereinbefore step a) further comprising step 1) freezing the cyanobacteria.

Paragraph 276. The product of the process of Paragraph 266, whereinbefore step a) further comprising step 1) drying the cyanobacteria.

Paragraph 277. A method of Paragraph 166, wherein the applying thecomposition is for at least 14 days.

Paragraph 278. A method of Paragraph 277, wherein the applying thecomposition is for at least 30 days.

Paragraph 279. A method of Paragraph 169, wherein the applying thecomposition is for at least 14 days.

Paragraph 280. A method of Paragraph 279, wherein the applying thecomposition is for at least 30 days.

Paragraph 281. A method of Paragraph 172, wherein the applying thecomposition is for at least 14 days.

Paragraph 282. A method of Paragraph 281, wherein the applying thecomposition is for at least 30 days.

Paragraph 283. A method of Paragraph 175, wherein the applying thecomposition is for at least 14 days.

Paragraph 284. A method of Paragraph 283, wherein the applying thecomposition is for at least 30 days.

Paragraph 285. A method of Paragraph 178, wherein the applying thecomposition is for at least 14 days.

Paragraph 286. A method of Paragraph 285, wherein the applying thecomposition is for at least 30 days.

Paragraph 287. A method of Paragraph 181, wherein the applying thecomposition is for at least 14 days.

Paragraph 288. A method of Paragraph 287, wherein the applying thecomposition is for at least 30 days.

Beneficial Effects of Extracts

Regeneration of the skin to reestablish permanent improvement and “skinage” of decades earlier.

Healing of the ulcers of the skin of the elderly and diabetics.

Used for diabetic skin to regenerate the blood vessels that have beendestroyed or altered by diabetes.

Improve the thickness and function of all skin that it is applied to,and most specifically bruising and extreme weakness of skin of theelderly. This product not only minimizes the bruising but adds strengthto minimize any tearing of the skin.

Increasing the thickness, strength and elasticity of the skin, wrinklesof all sorts, especially of sun damaged or aged skin (vs. muscularwrinkles) can be virtually erased. And even muscular wrinkles e.g.between the eyes and in the laugh lines can be minimized with thisproduct.

Stimulation of the immune system is through the T cell mediated system,which is the most efficient way of killing pre-cancers and cancers.

Systemic absorption of this product will also be used as a supplement tostrengthen the internal organs similar to the effects of the skin intopical application.

Systemic administration will be used to treat internal carcinomas andsarcomas.

Effective against rosacea and other prominent cutaneous blood vesselabnormalities.

Can be used in cream, gel, plasma, lotion, ointment, powder, capsule,tablet, liquid, spray, foam, solution, facial mask, skin mask, topicalapplication, etc.

Examples

Extract Trial Study

The study had a sample size of 283 people and none of the subjectsdropped out during the study. The distribution of subjects was 151 malesand 132 females (FIG. 1 ), and an age distribution from 14 to 101 years(FIG. 2 ). The ethnicity of the subjects was 275 Caucasians, 6 Asiansand 2 African-American.

Table 1 shows the distribution of skin of afflictions with agedistribution.

TABLE 1 Number and Number and Number and Number and (%) of subjectsNumber and (%) of subjects Age (%) of subjects (%) of subjects with (%)of subjects with Groups in each group with Wrinkles “Rosacea” withBruising Thin Skin  0-19 3 0 0 0 0  (1.06%)    (0%)   (0%)   (0%)   (0%)20-29 3 0 1 0 0  (1.06%)    (0%) (33.3%)   (0%)   (0%) 30-39 13 5 3 0 1 (4.59%)  (38.5%) (23.1%)   (0%)  (7.7%) 40-49 32 28 5 2 18 (11.30%)(87.50%) (15.6%)  (6.3%) (56.3%) 50-59 49 49 9 11 40 (17.31%)   (100%)(18.4%) (22.4%) (81.6%) 60-69 89 89 35 67 89 (31.44%)   (100%) (39.3%)(75.3%)  (100%) 70-79 62 62 41 57 62 (21.90%)   (100%) (66.1%)   (92%) (100%) 80-89 25 25 20 25 25  (8.83%)   (100%)   (80%)  (100%)  (100%)90-99 6 6 6 6 6  (2.12%)   (100%)  (100%)  (100%)  (100%) 100+ 1 1 1 1 1 (0.35%)   (100%)  (100%)  (100%)  (100%)

None of the subjects had an allergic reactions, even though 14 subjectshad seafood allergies. Five to 15 treatments of the extract compositionled to substantial improvement. 95% of subjects saw across the boardimprovements after 15 applications: lessening of wrinkles, thickening ofthe skin.

The first observed improvement was the fine wrinkles over the face (FIG.3 ). Four to 5 treatments were enough for 60% of the subjects to noticeimprovements in the cheek wrinkles. Similar improvements on the lowereyelids are expected after 5 to 15 treatments. The first areas ofimprovement are under the eyelids followed by wrinkles, thin skin, andthe disappearance of rosacea. Rosacea improved or disappeared after20-30 treatments.

The last observed effect was the disappearance of bruising of the skin.Approximately, 60-75% of the subjects had noticeable differences by30^(th) application. The improvement is exponential after about the15^(th) application.

50% of the subjects had 50% improvement in fine wrinkles of the faceafter 15 applications and 100% of the subjects had 50% or moreimprovement after 30 applications

20% of the subjects saw a significant improvement in thin skin after 15applications 95% of subjects in 30 applications

10% of subjects saw significant changes in Rosacea after 15 applicationsand 95% of subjects saw significant changes after 30 applications

0% of the subjects saw significant changes in bruising after 15applications and 65% of the subjects saw significant changes from 30applications

Histological Examination of Pre-Treatment and Post-Treatment Biopsies

A 60 year old male applied the extract to the surface on the top of onehand for 30 days. The other hand remained un-treated. After thecompletion of the 30 days of treatment, a 2 mm biopsies of skin weretaken from both the treated and untreated hand.

The skin biopsies were prepared for histological examination and stainedwith hematoxylin and eosin.

A microscopic examination of the biopsies showed that there were 35times more fibrocytes (producers of collagen, elastin and hyaluronicacid) in the post-treatment sample (FIG. 4 ) compared to thepre-treatment sample (FIG. 5 ).

The pre-treatment sample had only one blood vessel in the biopsiescompared to thirteen blood vessels in the post-treatment, even though itwas the same amount of tissue. The increase in the number of bloodvessels facilitates the distributions of the raw materials needed forimproving the skin.

The epidermis in pre-treatment tissue biopsy is thin with degenerativecollagen, which is characteristic of sun-damaged and aged skin comparedto the epidermis in post-treatment tissue biopsies which is thicker withhealthy collagen. The post-treatment tissue sample has many young cellsthat are huge, plump and vivacious.

The post-treatment biopsy contracted almost 33% in length and width dueto regained elasticity. The post-treatment is actually 33% wider and 33thicker than shown compared to the pre-treatment biopsy. (Tissue samplesshown at 40× magnification).

A visual examination of the skin on the hands showed a noticeabledifference in appearance between the treated and untreated hands (FIG. 6)

Effects of Extracts

The extracts from the disclosed marine organisms (abalone, algae,cyanobacteria, bivalves, sea cucumbers and crustaceans have been foundto rejuvenate the epidermis and papillary dermis, stimulate theproduction of fibrocytes and capillaries; stimulate the fibrocytes toproduce collagen, elastin and hyaluronic acid; stimulate Langerhan'scells to activate T cells to kill malignant cells, stimulate developmentof granulation tissue and reepithelialization of wounds, ulcers andburns. Additionally, the extracts contain antioxidants, polypeptides,vitamins, minerals, and antifungal and antibacterial agents that assistthe active ingredients in producing the observed effects.

What is claimed is:
 1. A topical composition comprising a first tissueextract from abalone and a second tissue extract from sea cucumber,wherein the topical composition is suitable for dermatologicapplication, and the first tissue extract and the second tissue extractare lyophilized; and the first tissue extract and the second tissueextract are present at concentrations such that the composition istherapeutically effective to treat a subject affected with rosacea. 2.The composition of claim 1 wherein the composition is useful fortreating rosacea when applied to skin and wherein daily application ofthe composition to affected skin of a subject with rosacea for 30 daysresults in a significant improvement or disappearance of rosacea.
 3. Thecomposition of claim 1 wherein application of the composition to skin ofa subject results in a significant improvement of one or more of finewrinkles, easily bruised skin, and thin skin.
 4. The composition ofclaim 1 wherein the second tissue extract is produced by a process ofextraction by a polar solvent, optionally wherein the polar solvent isselected from the group consisting of dimethyl sulfoxide (DMSO),isopropyl alcohol, ethanol, methanol, and acetic acid.
 5. Thecomposition of claim 4 wherein the polar solvent is DMSO.
 6. Thecomposition of claim 2 wherein the first tissue extract is a polarsolvent extract, a non-polar solvent extract, or a combination thereof.7. The composition of claim 1 wherein the sea cucumber is selected fromthe group consisting of Holothuria mexicana, Holothuria californica,Holothuria scabra, Stichopus chlorontus, Stichopus horrens, Stichopusjaponicus, Apostichopus japonicus, and Cucumaria japonica.
 8. Thecomposition of claim 1 wherein the second tissue extract is extractedfrom at least one sea cucumber part selected from the group consistingof body walls, muscles, visceras, and gonads.
 9. The topical compositionof claim 1, wherein the second tissue extract is produced by a processof extraction by a dimethyl sulfoxide (DMSO), wherein the topicalcomposition is suitable for dermatologic application, and whereinapplication of the composition to the skin of a subject causes anincrease in production of collagen, elastin, hyaluronic acid,fibrocytes, and new blood vessels.
 10. A method of treatment of asubject in need thereof comprising the step of administering acomposition of claim
 1. 11. The method of claim 10 wherein theadministration step is a step of topical administration.